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    Coupling of mitosis to the completion of S phase through Cdc34-mediated degradation of Wee1 (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-12-04
    Description: The dependence of mitosis on the completion of the period of DNA replication in the cell cycle [synthesis (S) phase] ensures that chromosome segregation occurs only after the genome has been fully duplicated. A key negative regulator of mitosis, the protein kinase Wee1, was degraded in a Cdc34-dependent fashion in Xenopus egg extracts. This proteolysis event was required for a timely entrance into mitosis and was inhibited when DNA replication was blocked. Therefore, the DNA replication checkpoint can prevent mitosis by suppressing the proteolysis of Wee1 during S phase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michael, W M -- Newport, J -- R01GM44656/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Dec 4;282(5395):1886-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of California, San Diego, La Jolla, CA 92093-0347, USA. wmichael@biomail.ucsd.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9836638" target="_blank"〉PubMed〈/a〉
    Keywords: Anaphase-Promoting Complex-Cyclosome ; Animals ; Aphidicolin/pharmacology ; Cell Cycle Proteins/metabolism ; Cell Nucleus/metabolism ; Cyclin-Dependent Kinase Inhibitor p27 ; DNA Replication/drug effects ; Female ; G2 Phase ; Leupeptins/pharmacology ; Ligases/*metabolism ; Male ; Maturation-Promoting Factor/metabolism ; Microtubule-Associated Proteins/metabolism ; *Mitosis ; *Nuclear Proteins ; Okadaic Acid/pharmacology ; Ovum ; Phosphoprotein Phosphatases/metabolism ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Tyrosine Kinases/*metabolism ; Proteins ; Recombinant Proteins/metabolism ; *S Phase ; Spermatozoa ; *Tumor Suppressor Proteins ; *Ubiquitin-Protein Ligase Complexes ; Ubiquitin-Protein Ligases ; Ubiquitins/analogs & derivatives/metabolism/pharmacology ; Xenopus ; *Xenopus Proteins ; cdc25 Phosphatases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    FFA-1, a protein that promotes the formation of replication centers within nuclei (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1995-09-29
    Description: In the nuclei of eukaryotic cells, initiation of DNA replication occurs at a discrete number of foci. One component of these foci is the DNA replication factor RP-A. Here, the process leading to the association of RP-A with foci was reconstituted with cytosolic fractions derived from Xenopus eggs. With the use of this fractionated system, a 170-kilodalton protein required for the assembly of RP-A into foci was identified and purified. The protein appears to be an integral component of the foci at which replication of DNA is initiated in eukaryotic nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yan, H -- Newport, J -- GM33523/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1995 Sep 29;269(5232):1883-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉University of California, San Diego, Department of Biology, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7569932" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/*metabolism ; Cell-Free System ; Cytosol/chemistry ; *DNA Replication ; DNA, Single-Stranded/metabolism ; DNA-Binding Proteins/*metabolism ; Female ; Male ; Molecular Weight ; Oocytes ; Orientation ; Proteins/chemistry/*metabolism ; Replication Protein A ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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