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  • 1
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    Expression of the multidrug-resistant gene in hepatocarcinogenesis and regenerating rat liver (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-05-29
    Description: Preneoplastic and neoplastic liver nodules and hepatocytes isolated from regenerating rat liver have been shown to be resistant to a broad range of carcinogenic agents. This phenomenon was studied by measuring the expression of the multidrug-resistant (mdr) gene in normal liver cells and in preneoplastic and neoplastic nodules and regenerating liver. Levels of messenger RNA for the mdr gene, which encodes P-glycoprotein, were elevated in both preneoplastic and neoplastic lesions. Expression of the mdr gene also reached high levels in regenerating rat liver 24 to 72 hours after partial hepatectomy. These results show that the expression of the mdr gene can be regulated in liver and is likely to be responsible for part of the multidrug-resistance phenotype of carcinogen-initiated hepatocytes and regenerating liver cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thorgeirsson, S S -- Huber, B E -- Sorrell, S -- Fojo, A -- Pastan, I -- Gottesman, M M -- New York, N.Y. -- Science. 1987 May 29;236(4805):1120-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3576227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Carcinogens/*pharmacology ; Drug Resistance/*genetics ; *Genes ; Humans ; Liver/drug effects ; Liver Neoplasms, Experimental/chemically induced ; Liver Regeneration/*drug effects ; Male ; Precancerous Conditions/chemically induced ; RNA, Messenger/genetics ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-12-04
    Description: The epidermal growth factor (EGF) receptor gene EGFR has been placed in a retrovirus vector to examine the growth properties of cells that experimentally overproduce a full-length EGF receptor. NIH 3T3 cells transfected with the viral DNA or infected with the corresponding rescued retrovirus developed a fully transformed phenotype in vitro that required both functional EGFR expression and the presence of EGF in the growth medium. Cells expressing 4 x 10(5) EGF receptors formed tumors in nude mice, while control cells did not. Therefore, the EGFR retrovirus, which had a titer on NIH 3T3 cells that was greater than 10(7) focus-forming units per milliliter, can efficiently transfer and express this gene, and increased numbers of EGF receptors can contribute to the transformed phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Velu, T J -- Beguinot, L -- Vass, W C -- Willingham, M C -- Merlino, G T -- Pastan, I -- Lowy, D R -- New York, N.Y. -- Science. 1987 Dec 4;238(4832):1408-10.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3500513" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Transformation, Neoplastic/chemically induced/*genetics ; Cells, Cultured ; DNA, Recombinant ; Epidermal Growth Factor/*pharmacology ; Fibroblasts/pathology ; Genetic Vectors ; Harvey murine sarcoma virus/genetics ; Humans ; Male ; Mice ; Mice, Nude ; Neoplasms, Experimental/etiology ; *Proto-Oncogenes ; Receptor, Epidermal Growth Factor/drug effects/*genetics ; Recombinant Proteins/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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