Publication Date:
1985-06-07
Description:
The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Daniel, M D -- Letvin, N L -- King, N W -- Kannagi, M -- Sehgal, P K -- Hunt, R D -- Kanki, P J -- Essex, M -- Desrosiers, R C -- AI20729/AI/NIAID NIH HHS/ -- CA13885/CA/NCI NIH HHS/ -- CA38205/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1985 Jun 7;228(4704):1201-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3159089" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/*veterinary
;
Animals
;
Lymphoma/microbiology/veterinary
;
Macaca/*microbiology
;
Macaca mulatta/*microbiology
;
Monkey Diseases/*microbiology
;
Retroviridae/*isolation & purification
;
T-Lymphocytes/*microbiology
;
T-Lymphocytes, Helper-Inducer/microbiology
;
Virus Replication
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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