Publication Date:
1983-08-12
Description:
Female macaque monkeys self-administered high doses of alcohol (2.9 to 4.4 grams per kilogram per day) for 3 to 6 1/2 months. Amenorrhea, atrophy of the uterus, decreased ovarian mass, and significant depression of luteinizing hormone levels were associated with chronic alcohol intoxication. Reproductive system failure in female primates following self-induced dependence on alcohol parallels the results of clinical studies of alcoholic women.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mello, N K -- Bree, M P -- Mendelson, J H -- Ellingboe, J -- King, N W -- Sehgal, P -- AA 04368/AA/NIAAA NIH HHS/ -- RR-00168-21/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1983 Aug 12;221(4611):677-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6867739" target="_blank"〉PubMed〈/a〉
Keywords:
Alcoholism/*physiopathology
;
Amenorrhea/chemically induced
;
Animals
;
Ethanol/adverse effects
;
Female
;
Humans
;
Luteinizing Hormone/blood
;
Macaca
;
Menstruation/drug effects
;
Ovary/drug effects
;
Pituitary Gland, Anterior/drug effects
;
Reproduction/*drug effects
;
Uterus/drug effects
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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