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  • Polymer and Materials Science  (9)
  • Lunar and Planetary Science and Exploration  (8)
  • MAN/SYSTEM TECHNOLOGY AND LIFE SUPPORT  (8)
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  • 1
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Biopolymers 41 (1997), S. 521-532 
    ISSN: 0006-3525
    Keywords: recombinant DNA ; pH responsive hydrophobic microdomains ; dn31 gene ; gel filtration chromatography ; CD ; fluorescence probe analysis ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Recombinant DNA technology has been employed to produce a polypeptide capable of forming pH responsive hydrophobic microdomains. The design of this peptide is based upon an idealized conceptual model in which electrostatic, hydrophobic, and hydration forces are responsible for the association of amphipathic α-helical elements. Reduction in solution pH is responsible for reducing electrostatic repulsions between similarly charged residues, promoting the hydrophobic collapse of helical elements. A polymerizable synthetic element (dn31) has been synthesized and inserted into an appropriate expression vector. A clone containing a single copy of the dn31 gene (designated dn31x1) was isolated and the corresponding gene product DN3Lx1 isolated. The physical properties of DN3Lx1 were examined in solution by gel filtration chromatography, CD, and fluorescence probe analysis. It was determined that DN3Lx1 self-associates in solution with the degree of aggregation dependent on pH and ionic strength. An initial objective of this work was to examine domain organization in higher molecular weight species containing ten or more repetitive sequences. However, attempts to express multiple repeats of DN3Lxn from concatemers were unsuccessful. © 1997 John Wiley & Sons, Inc. Biopoly 41: 521-532, 1997.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Polymer Science: Macromolecular Reviews 11 (1976), S. 209-275 
    ISSN: 0076-2083
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 59 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 14 (1980), S. 279-288 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This research is part of a continuing program for the development of a coaxial depth electrode for research and diagnostic studies of neurological diseases. The requirements for this electrode include (1) strength and resistance to buckling sufficient to ensure self-forced penetration of brain tissue to a depth of 6 cm; (2) biocompatibility of the materials employed; (3) resistance to brittle fracture; and (4) a total diameter of less than 200 μm to minimize tissue damage. Earlier synthesis efforts using chemical vapor deposition techniques have been successful, although the process yield was 40% and an outer insulating layer had yet to be deposited. Plasma polymerization processes have been employed to realize an increase in the yield and provide an outer insulating layer. The starting material is W-26 at.% Re wire, nominally 125 μm in diameter. Hexamethyldisilazane (CH3)3SiNHSi(CH3)3 is used to deposit the insulating layers. The paper describes factors influencing the choice of materials, deposition techniques, and properties of electrodes.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 10 (1976), S. 805-828 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The vital first phase of the overall materials study to protract the life of the total joint replacements is the identification of the fracture toughness and fatigue properties of bone cements. Information gained from fatigue testing, performed in a manner which simulates in vivo conditions, and fracture toughness, which is a measure of the propensity of a crack to propagate, is the first step towards the prediction of the life of the total joint replacement. This study is concerned with the fracture toughness of Zimmer and Simplex-P cold-curing bone cements.Following cement fabrication conditions which closely approximate clinical procedures, fracture toughness testing was conducted on cement specimens which were immersed in bovine serum at 37°C in order to simulate in vivo conditions. In addition, a similar study was completed on specimens, tested in air at ambient temperature for purposes of comparison. Results of this procedure, when analyzed by a Student's t-test at the 95% confidence level with eight degrees of freedom, indicate that both Zimmer and Simplex-P exhibit a higher fracture toughness in the simulated physiological environment.In order to determine whether the addition of barium sulfate to these cements compromises the fracture toughness, the above described testing rationale was repeated, indicating the existence of a complicated relationship between the different testing environments and barium sulfate. The importance of these results lies in the fact that an increased fracture toughness indicates that a cement will inherently exhibit a greater degree of resistance to the propagation of cracks, which could contribute to the ultimate failure of the total joint replacement.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 11 (1977), S. 609-624 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The vital first phase of the overall materials study to protract the life of total joint replacements is the identification of the fracture toughness and fatigue properties of bone cements. Information gained from fatigue testing, performed in a manner which simulates in vivo conditions, and fracture toughness, which is a measure of the propensity of a crack to propagate, is the first step towards the prediction of the life of the total joint replacement. Part I of this study identified the fracture toughness characteristics of two acrylic bone cements, while the present work has been concerned with determining the fatigue behavior by means of tests conducted in a rotating bending fatigue apparatus. Fatigue specimens were fabricated under conditions which approximated clinical procedures and then tested while immersed in bovine serum at 37°C in order to simulate in vivo conditions. In addition, a similar study was completed on specimens tested in air at ambient temperature for purposes of comparison. Testing was conducted in both of these environments on specimens containing zero and 10.0 wt % BaSO4. Cyclic loading frequency was maintained between 1200 and 1400 cycles/min in order to insure that crack propagation was the sole mechanism of failure, i.e., failure via cyclic thermal softening was obviated.Results of this phase of the study, when analyzed by a Student t-test at the 90% confidence level with four degrees of freedom, indicate that the fatigue life of specimens tested in bovine serum at 37°C is superior to that of specimens tested in air at ambient temperature. The addition of BaSO4 to Simplex-P cement, while not significant at the 90% confidence level, was significant in increasing the fatigue life in air at the 80% confidence level; however, this effect was not noticeable when testing in bovine serum at 37°C. Examination of the fracture surfaces enabled calculation of the critical stress intensity factor which when compared with values from an earlier work showed good agreement.
    Additional Material: 7 Ill.
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  • 6
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Conventional polyurethane prepolymers have been shown to adhere to living biological tissues. However, their setting is not sufficiently expedient to permit convenient applications in vivo. A prepolymer prepared from the highly reactive 6-chloro-2,4,5-trifluoro-1,3-phenylene diisocyanate, castor oil, and a trace of pyridine has afforded an adhesive which sets in about 2 min in vivo. The fast setting has resulted in poor adhesion on biological tissue. The bonding has been improved by the inclusion of tolylene diisocyanate in the composition without affecting the fast curing rate of the prepolymer. The dispersion of the adhesive and its cohesion after solidification have been adjusted by other minor additives. Preliminary evaluation on animals indicates that this adhesive is most useful as a hemostatic coating in hepatic lacerations.
    Additional Material: 1 Ill.
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  • 7
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 13 (1979), S. 343-343 
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 17 (1979), S. 1957-1964 
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A version of the surface growth method by Zwijnenburg and Pennings is being used to produce blended fibers of polyethylene and polypropylene under conditions where polypropylene does not yield to this fiber growth technique but would grow films. The blended fiber contains intimately mixed crystalline regions of each pure component and combines thermal and mechanical properties of both. The growth method itself underlines the part played by adsorbed surface layers and entanglements within such layers which can involve the entanglement of chemically different species. This feature suggests a potentially new method for blend production.
    Additional Material: 6 Ill.
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  • 9
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 19 (1981), S. 1047-1053 
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Work on the surface-growth method of producing blend films from mixed solutions of two polymers has exposed a random fluctuation in both growth rate and composition of the blend film with time of deposition. The effects are explained by heterogeneous separation of the two polymer components in the solution induced by the stirring action of the rotor of the Couette apparatus used. The solution is thus converted to a colloidal sol which on cooling forms a gel which exhibits syneresis at room temperature. The sol-to-gel transition is thermally reversible.
    Additional Material: 6 Ill.
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  • 10
    Publication Date: 2013-08-31
    Description: In addition to cooperative dynamic control, the system incorporates real time vision feedback, a novel programming technique, and a graphical high level user interface. By focusing on the vertical integration problem, not only these subsystems are examined, but also their interfaces and interactions. The control system implements a multi-level hierarchical structure; the techniques developed for operator input, strategic command, and cooperative dynamic control are presented. At the highest level, a mouse-based graphical user interface allows an operator to direct the activities of the system. Strategic command is provided by a table-driven finite state machine; this methodology provides a powerful yet flexible technique for managing the concurrent system interactions. The dynamic controller implements object impedance control; an extension of Nevill Hogan's impedance control concept to cooperative arm manipulation of a single object. Experimental results are presented, showing the system locating and identifying a moving object catching it, and performing a simple cooperative assembly. Results from dynamic control experiments are also presented, showing the controller's excellent dynamic trajectory tracking performance, while also permitting control of environmental contact force.
    Keywords: MAN/SYSTEM TECHNOLOGY AND LIFE SUPPORT
    Type: JPL, California Inst. of Tech., Proceedings of the NASA Conference on Space Telerobotics, Volume 3; p 341-350
    Format: application/pdf
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