ISSN:
1432-1041
Keywords:
Loperamide
;
loperamide oxide
;
diarrhoea
;
pharmacokinetics
;
dose-proportionality
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetics of loperamide, after oral administration of increasing doses (1 to 16 mg) of loperamide oxide, has been investigated in 10 healthy male volunteers, using a randomised cross-over design. Comparison of the maximum plasma loperamide concentration and AUC demonstrated that the bioavailability of loperamide was proportional to the dose of loperamide oxide administered.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00265940
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