ISSN:
1420-9071
Keywords:
Lithium
;
mechanism
;
choline
;
lecithin
;
glycerophosphorylcholine
;
phosphorylcholine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary The influence of oral lithium on the concentration of red blood cell choline (Ch), lecithin, glycerophosphorylcholine (GPCh) and phosphorylcholine (PCh) was studied. The concentration of RBC Ch was significantly elevated and the concentration of lecithin, GPCh and PCh significantly depressed in 16 patients on oral lithium compared to 9 age-matched controls. We conclude that lithium markedly depletes the red blood cell of choline containing compounds including lecithin. These changes may be responsible for both the therapeutic efficacy and the toxicity of lithium.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01954227
Permalink