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  • 1
    Electronic Resource
    Electronic Resource
    Condensation of activated diguanylates on a poly(C) template (1981)
    Springer
    Journal of molecular evolution 17 (1981), S. 303-306 
    Details
    ISSN: 1432-1432
    Keywords: Imidazolides ; Diguanylates ; Poly(C) ; Directed condensations ; Linkage isomerism ; Prebiotic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have studied the metal-ion catalysis of a number of reactions of the isomers of ImpGpG on a poly(C) template. In the absence of a catalytic metal ion, oligomers at least up to (pG)20 are obtained from the ImpGpG isomers in a l-methylimidazole buffer. The Pb2+ ion improves the yield of longer oligomers and changes substantially the distribution of linkage isomers. The Pb2+ ion greatly improves the yield of longer oligomers obtained from G and ImpGpG on a poly(C) template. The self-condensation of ImpGpG in a 2, 6-lutidine buffer is much less efficient than in a l-methylimidazole buffer. The Zn2+ greatly increases the yield of products from the [3′-5′]-linked dimer, but fails to catalyze the formation of long oligomers from the [2′-5′]-linked dimer. The bonds formed in the Zn2+-catalyzed selfcondensation of ImpG3pG on poly(C) are mainly [3′-5′]-linked.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01795752
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  • 2
    Electronic Resource
    Electronic Resource
    Self-condensation of activated dinucleotides on polynucleotide templates with alternating sequences (1979)
    Springer
    Journal of molecular evolution 14 (1979), S. 243-250 
    Details
    ISSN: 1432-1432
    Keywords: Template-directed condensation ; Phosphorimidazolides ; Oligonucleotides with alternating sequence ; Linkage isomerism ; Prebiotic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We have prepared substantial quantities of the alternating polymers poly(U-G) and poly(C-A) and have used them as templates for the self-condensation of ImpApC, ImpCpA, ImpGpU and ImpUpG. We find that the condensation of ImpGpU and ImpUpG on poly(C-A) is efficient, the condensation of ImpCpA on poly(U-G) is moderately efficient, while the condensation of ImpApC on poly(U-C) proceeds poorly. In many cases, the product is predominantly 3′-5′-linked. These reactions demonstrate unequivocally, for the first time, that template-directed reactions occur in double-helical structures. Furthermore, they describe for the first time a pair of reactions in which each of two complementary polymers facilitates the synthesis of the other. The prebiotic significance of these findings is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01732491
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