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  • Life and Medical Sciences  (2)
  • Mus musculus  (1)
  • Y chromosome  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Restriction fragment polymorphism in the sex-determining region of the Y chromosomal DNA of European wild mice (1988)
    Springer
    Molecular genetics and genomics 212 (1988), S. 440-449 
    Details
    ISSN: 1617-4623
    Keywords: Bkm DNA ; Polymorphism ; Wild Mouse ; Y chromosome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Using 32P-labeled probe consisting mainly of (GATA)n we have shown that a male specific Alu1 DNA blot pattern which defines the Y chromosome sex-determining locus in inbred mice is highly polymorphic in wild mice, indicating substantial sequence evolution in this region under field conditions. In all cases examined by in situ hybridization, the region concerned is paracentromeric. In contrast, the blot pattern of another probe (M 34) which detects repeated sequences specific to the mouse Y chromosome but outside the sex-determining locus, remains constant between different isolates.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00330848
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  • 2
    Electronic Resource
    Electronic Resource
    Meiotic synapsis of homogeneously staining regions (HSRs) in chromosome 1 ofMus musculus (1993)
    Springer
    Chromosome research 1 (1993), S. 37-44 
    Details
    ISSN: 1573-6849
    Keywords: HSRs ; meiotic synapsis ; Mus musculus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract About 50 copies of a long-range repeat DNA family with a repeat size of roughly 100 kb and with sequence homology to mRNAs are clustered in the G-light band D of chromosome 1 of the house mouse,Mus musculus. We studied amplified versions of the cluster which are found in many wild populations ofM. musculus. They are cytogenetically conspicuous as one or two C-band positive homogeneously staining regions (single- and double band HSRs) which increase the mitotic length of chromosome 1. The double band HSR was phylogenetically derived from a single band HSR by a paracentric inversion. In homozygous condition, such HSRs contribute, albeit not as much as expected from their mitotic length, to the synaptonemal complex (SC) length of chromosome 1. In HSR heterozygous animals an elongation of the SCs was not noticeable. In single band HSR heterozygous males, synapsis proceeds regularly and continuously from the distal telomere towards the centromeric end without forming buckles. Thus, the single band HSR has no adverse effect on pairing. The same straight pairing behaviour was found in the majority of double band HSR heterozygous spermatocytes. This shows that extensive nonhomologous pairing can take place in the earliest phase of synapsis. Synapsis was discontinuous, leaving the central part of the bivalent 1 asynapsed, in only 14.3% of double band HSR heterozygous cells. In such cells the chromosome 1 SC is completed at a later stage of meiosis. The delay is presumably an effect of the inversion that includes one HSR band and the segment between the two HSR bands.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00710605
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  • 3
    Electronic Resource
    Electronic Resource
    Protamine amount and cross linking in mouse teratospermatozoa and aneuploid spermatozoa (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 25 (1990), S. 297-301 
    Details
    ISSN: 1040-452X
    Keywords: Chromosome mutations ; Mutations ; Spermatozoa ; Mouse protamine ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The level of SH-group oxidation in spermatozoa from the cauda epididymis was measured by a cytofluorometric method in chromosomally normal mice and two chromosome mutants. The first one, a tertiary trisomic karyotype (Ts(113)7OH), is characterized by severe oligospermia and high levels (≈75%) of malformed spermatozoa. The second, a hybrid between two European feral mouse stocks, is heterozygous for multiple Robertsonian translocations and produces exclusively aneuploid spermatozoa. Neither the severe teratospemiogenesis nor the severe aneuploidy was reflected in total SH-group fluorescence values nor in free SH-group fluorescence. It is concluded that both the production of protamines and protamine cross linking by S-S bridge formation are rather autonomous processes during spermatogenesis because (1) the increased DNA variance of the aneuploid spermatozoa is not reflected in an increased variance of the total and free SH-groups, (2) aneuploidy for the protamine gene carrying chromosome 16 is not reflected by the SH-group values for individual spermatozoa, and (3) protamine production and cross linking are independent of the mild to severe terataspermiogenesis in the tertiary trisomic karyotype.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080250312
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  • 4
    Electronic Resource
    Electronic Resource
    Spermatozoa of chromosomally heterozygous mice and their fate in male and female genital tracts (1984)
    New York, NY : Wiley-Blackwell
    Gamete Research 9 (1984), S. 273-286 
    Details
    ISSN: 0148-7280
    Keywords: mouse spermatozoa ; Robertsonian chromosomes ; DNA content ; sperm aneuploidy ; genital tracts ; prezygotic selection ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: The fate of morphologically normal but chromosomally abnormal spermatozoa derived from mice with variable degrees and complexity of Robertsonian heterozygosity was studied at different sites along the male and female genital tract by Feulgen-DNA measurements. In addition, the percentage frequencies of morphologically abnormal spermatozoa in transit along the male and female genital tracts were studied.It was found that during transit from the epididymis to the vas deferens the distribution of the Feulgen-DNA contents of morphologically normal spermatozoa changed: Spermatozoa with chromatin with the extremely low or high Feulgen staining intensity disappeared. The percentages of morphologically abnormal sperm cells did not change at these levels. In the female genital tracts, the distribution of Feulgen-DNA content of morphologically normal spermatozoa did not show significant changes. This indicates that spermatozoa are able to reach the fallopian tube in spite of gross genome unbalance. There is evidence that unbalanced spermatozoa take part in the fertilization process, producing abnormal zygotes subject to postzygotic loss. Conversely morphologically abnormal spermatozoa were preferentially lost before they reached the fallopian tube, suggesting they had been eliminated prezygotically.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1120090305
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