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  • Life Sciences (General)  (1)
  • Little Ice Age  (1)
  • 1
    Publication Date: 2022-08-19
    Description: Author Posting. © American Geophysical Union, 2022. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Paleoceanography and Paleoclimatology 37, (2022): e2021PA004379, https://doi.org/10.1029/2021pa004379.
    Description: Atlantic Meridional Overturning Circulation (AMOC) plays a central role in the global redistribution of heat and precipitation during both abrupt and longer-term climate shifts. Over the next century, AMOC is projected to weaken due to greenhouse gas warming, though projecting its future behavior is dependent on a better understanding of how AMOC changes are forced. Seeking to resolve an apparent contradiction of AMOC trends from paleorecords of the more recent past, we reconstruct seawater cadmium, a nutrient-like tracer, in the Florida Straits over the last ∼8,000 years, with emphasis on the last millennium. The gradual reduction in seawater Cd over the last 8,000 years could be due to a reduction in AMOC, consistent with cooling Northern Hemisphere temperatures and a southward shift of the Intertropical Convergence Zone. However, it is difficult to reconcile this finding with evidence for an increase in geostrophic flow through the Florida Straits over the same time period. We combine data from intermediate water depth sediment cores to extend this record into the Common Era at sufficient resolution to address the broad scale changes of this time period. There is a small decline in the Cd concentration in the Late Little Ice Age relative to the Medieval Climate Anomaly, but this change was much smaller than the changes observed over the Holocene and on the deglaciation. This suggests that any trend in the strength of AMOC over the last millennium must have been very subtle.
    Description: This work was funded by the NSF Graduate Research Fellowship DGE-1148903 (SV) and NSF grant OCE-1459563 and OCE-1851900 (JLS).
    Keywords: AMOC ; seawater cadmium ; Florida Straits ; Holocene ; Little Ice Age
    Repository Name: Woods Hole Open Access Server
    Type: Article
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  • 2
    Publication Date: 2019-07-19
    Description: Considering the range of functions proteins perform, it is surprising they fold into a relatively small set of structures or "folds" that facilitate such function. One explanation is that only a minority were fit enough to emerge from Darwinian selection during the early evolution of life. Alternatively, perhaps only a fraction of all possible folds were trialed. Understanding proto-catalyst selection will aid understanding of the origins and early evolution of life. To investigate which explanation is correct, we study a protein evolved in vitro to bind ATP by Jack Szostak (Fig. 1). This protein adopts a fold which is absent from nature. We are testing whether this fold would have possessed the capability to evolve that would have been essential to survive natural selection on early Earth. Folds that couldn't improve their fitness and evolve to perform new functions would have been replaced by rivals that could. To determine whether the fold is evolvable, we are attempting to change the function of the protein by rationally redesigning to bind GTP. Two design strategies in the region of the nucleobase have been implemented to provide hydrogen bonding partners for the ligand i) an insertion ii) a MET to ASN mutation. Redesigns are being studied computationally at Ames Research Center including free energy of binding calculations. Binding affinities of promising redesigns are to be validated by experimental collaborators at ForteBio using Super Streptavidin Biosensors. If the fold is found to be non-evolvable, this may suggest that many structures were trialed, but the majority were pruned on the basis of their evolvability. Alternatively, if the fold is demonstrated to be evolvable, it would be difficult to explain its absence from nature without considering the possibility that the fold simply wasn't sampled on early Earth. This would not only further our understanding of the origins of life on Earth but also suggest a common phe-nomenon of proto-catalyst evolution.
    Keywords: Life Sciences (General)
    Type: ARC-E-DAA-TN44730 , International Conference on the Origin of Life; Jul 16, 2017 - Jul 21, 2017; San Diego, CA; United States
    Format: application/pdf
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