Publication Date:
1984-06-29
Description:
Normal human colon mucosal epithelial cells were cultured in vitro and treated with the oncogenic simian DNA virus (SV40) and the chemical carcinogen azoxymethane. Both SV40 and azoxymethane altered a number of phenotypic characteristics of the normal human colon cells, including their morphology, culture longevity, growth in soft agar, substrate adherence, and peanut agglutinin binding. The SV40 transformants synthesized intranuclear T antigen. These data indicate that normal human colon mucosal cells were transformed toward the malignant phenotype.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moyer, M P -- Aust, J B -- RRO5654/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Jun 29;224(4656):1445-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6328655" target="_blank"〉PubMed〈/a〉
Keywords:
Antigens, Viral, Tumor/metabolism
;
Azoxymethane/pharmacology
;
Cell Transformation, Neoplastic/*physiopathology
;
Cells, Cultured
;
Colon/*cytology/drug effects
;
Colonic Neoplasms/physiopathology
;
Fibroblasts/drug effects
;
Humans
;
Lectins/pharmacology
;
Simian virus 40/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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