Publication Date:
2022-05-25
Description:
© 2014 The Author(s). This is an Open Access article. The definitive version was published in Invertebrate Reproduction & Development 59, Supple. 1 (2015): 5-10, doi:10.1080/07924259.2014.925516.
Description:
Comparative biogerontology has much to contribute to the study of aging. A broad range of aging rates have evolved to meet environmental challenges, and understanding these adaptations can produce valuable insights into aging. The supra Phylum Lophotrochozoa is particularly understudied and has several groups that have intriguing patterns of aging. Members of the Lophotrochozoan phylum Rotifera are particularly useful for aging studies because cohort life tables can be conducted with them easily, and biochemical and genomic tools are available for examining aging mechanisms. This paper reviews a variety of caloric restriction (CR) regimens, small molecule inhibitors, and dietary supplements that extend rotifer lifespan, as well as important interactions between CR and genotype, antioxidant supplements, and TOR and jun-N-terminal kinase (JNK) pathways, and the use of RNAi to identify key genes involved in modulating the aging response. Examples of how rapamycin and JNK inhibitor exposure keeps mortality rates low during the reproductive phase of the life cycle are presented, and the ease of conducting life table experiments to screen natural products from red algae for life extending effects is illustrated. Finally, experimental evolution to produce longer-lived rotifer individuals is demonstrated, and future directions to determine the genetic basis of aging are discussed.
Description:
We are grateful for the support of the National Institute of
Aging, [grant number R01 AG037960-02] for this work and
for a Postdoctoral Fellowship from the Ellison Medical Foundation/
American Federation for Aging Research to K. Gribble.
Keywords:
Comparative biogerontology
;
Caloric restriction
;
Antioxidants
;
TOR
;
JNK
;
Aging
;
Evolution
Repository Name:
Woods Hole Open Access Server
Type:
Article
Format:
application/pdf
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