ISSN:
1423-0127
Keywords:
Heat shock
;
Calcium
;
Sodium
;
Inositol 1,4,5-trisphosphate
;
Heat shock protein 70 kd
;
Intracellular pH
;
Protection
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Exposure of cells and organs to heat shock is associated with numerous changes in various cellular metabolic parameters and overexpression of proteins collectively known as heat shock proteins (HSP). In this communication we review the cell-signaling events that are altered in response to heat shock as they relate to the subsequent induction of HSP 70 kd (HSP-70) expression. We also review the mechanisms by which HSP-70 is involved in conferring cytoprotective effects. The possibility of altering HSP expression through manipulations of the cell-signal process has clinical importance.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02258043
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