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  • 1
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    Dominoes and clocks: the union of two views of the cell cycle (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-11-03
    Description: We review the recent advances in understanding transitions within the cell cycle. These have come from both genetic and biochemical approaches. We discuss the phylogenetic conservation of the mechanisms that induce mitosis and their implications for other transitions in the cell cycle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murray, A W -- Kirschner, M W -- New York, N.Y. -- Science. 1989 Nov 3;246(4930):614-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, School of Medicine, University of California, San Francisco 94143-0448.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2683077" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Cell Cycle ; *Genes, Regulator ; Interphase ; Mitosis ; *Models, Biological ; Models, Genetic ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    How to compact DNA (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-12-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Murray, A W -- New York, N.Y. -- Science. 1998 Oct 16;282(5388):425, 427.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of California at San Francisco, San Francisco, CA 94143-0444, USA. amurray@socrates.ucsf.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9841400" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/chemistry/*metabolism ; Adenosine Triphosphate/metabolism ; Animals ; CDC2 Protein Kinase/metabolism ; Carrier Proteins/metabolism ; *Cell Cycle Proteins ; *Chromosomal Proteins, Non-Histone ; Chromosomes/*metabolism/ultrastructure ; Cyclin B/metabolism ; DNA/chemistry/*metabolism ; DNA, Superhelical/chemistry ; DNA-Binding Proteins/chemistry/*metabolism ; Dosage Compensation, Genetic ; Female ; Interphase ; Male ; *Mitosis ; Multiprotein Complexes ; Nuclear Proteins/metabolism ; Nucleic Acid Conformation ; Phosphorylation ; Xenopus ; *Xenopus Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores (1996)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1996-10-11
    Description: The spindle assembly checkpoint delays anaphase until all chromosomes are attached to a mitotic spindle. The mad (mitotic arrest-deficient) and bub (budding uninhibited by benzimidazole) mutants of budding yeast lack this checkpoint and fail to arrest the cell cycle when microtubules are depolymerized. A frog homolog of MAD2 (XMAD2) was isolated and found to play an essential role in the spindle assembly checkpoint in frog egg extracts. XMAD2 protein associated with unattached kinetochores in prometaphase and in nocodazole-treated cells and disappeared from kinetochores at metaphase in untreated cells, suggesting that XMAD2 plays a role in the activation of the checkpoint by unattached kinetochores. This study furthers understanding of the mechanism of cell cycle checkpoints in metazoa and provides a marker for studying the role of the spindle assembly checkpoint in the genetic instability of tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, R H -- Waters, J C -- Salmon, E D -- Murray, A W -- New York, N.Y. -- Science. 1996 Oct 11;274(5285):242-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of California, San Francisco, 94143, USA. Chapel Hill, NC 27599, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8824188" target="_blank"〉PubMed〈/a〉
    Keywords: ATP-Binding Cassette Transporters/analysis/chemistry/genetics/*metabolism ; Amino Acid Sequence ; Animals ; Calcium/pharmacology ; *Cell Cycle ; Cells, Cultured ; HeLa Cells ; Humans ; Interphase ; Kinetochores/*metabolism ; Lamins ; Microtubules/metabolism ; Mitosis ; Molecular Sequence Data ; Nuclear Envelope/chemistry ; Nuclear Proteins/metabolism ; Ovum ; P-Glycoprotein/analysis/chemistry/genetics/*metabolism ; *P-Glycoproteins ; Protamine Kinase/metabolism ; Spindle Apparatus/*physiology ; Xenopus
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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