ISSN:
1573-3904
Keywords:
Acute phase proteins
;
Inflammation
;
Serine protease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Extended peptides that derive from the primary sequence of the acute phase reactant C-reactive protein (CRP) are shown to inhibit in vitro the enzymatic activities of human leukocyte elastase (hLE) and human leukocyte cathepsin G (hCG), which are associated with the tissue damage that occurs during the course of several chronic inflammatory conditions. Major inhibitory activity was observed in the peptides CRP70-98 and CRP50-98 towards hLE (Ki = 4.0 µM) and hCG (Ki = 1.4 µM), respectively. In contrast to the inability of intact CRP pentamers to inhibit both enzymes, CRP subunits (monomers) inhibited hLE (3.0 µM) and hCG (3.6 µM) activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008853715165
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