Publication Date:
2015-02-07
Description:
The layer of macrophages at the subcapsular sinus (SCS) captures pathogens entering the lymph node, preventing their global dissemination and triggering an immune response. However, how infection affects SCS macrophages remains largely unexplored. Here we show that infection and inflammation disrupt the organization of SCS macrophages in a manner that involves the migration of mature dendritic cells to the lymph node. This disrupted organization reduces the capacity of SCS macrophages to retain and present antigen in a subsequent secondary infection, resulting in diminished B cell responses. Thus, the SCS macrophage layer may act as a sensor or valve during infection to temporarily shut down the lymph node to further antigenic challenge. This shutdown may increase an organism's susceptibility to secondary infections.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gaya, Mauro -- Castello, Angelo -- Montaner, Beatriz -- Rogers, Neil -- Reis e Sousa, Caetano -- Bruckbauer, Andreas -- Batista, Facundo D -- Cancer Research UK/United Kingdom -- New York, N.Y. -- Science. 2015 Feb 6;347(6222):667-72. doi: 10.1126/science.aaa1300.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. ; Immunobiology Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. ; Lymphocyte Interaction Laboratory, London Research Institute, Cancer Research UK, 44 Lincoln's Inn Fields, London WC2A 3LY, UK. facundo.batista@cancer.org.uk.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25657250" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens/immunology
;
B-Lymphocytes/*immunology/pathology
;
Cell Movement/*immunology
;
Coinfection/*immunology
;
Dendritic Cells/immunology
;
Inflammation/*immunology
;
Lymph Nodes/immunology/pathology
;
Macrophages/*immunology/pathology
;
Mice
;
Mice, Inbred C57BL
;
Staphylococcal Skin Infections/*immunology
;
*Staphylococcus aureus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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