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  • 1
    Electronic Resource
    Electronic Resource
    Action of RH 5849, a non-steroidal ecdysteroid mimic, on Plodia interpunctella (Hübner) in vivo and in vitro (1990)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 15 (1990), S. 201-212 
    Details
    ISSN: 0739-4462
    Keywords: growth ; molting ; tissue culture ; IGR ; juvenile hormone ; methoprene ; chitin imaginal disc ; Indian meal moth ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We have examined the effects of RH 5849, a non-steroidal ecdysteroid mimic, on the growth and development of Plodia interpunctella. When RH 5849 was administered in the diet, larval growth was inhibited in a dose-dependent manner, while concentrations of 15 ppm and greater were highly toxic. However, the deleterious effects of RH 5849 could be prevented, except at very high concentrations of RH 5849, by the simultaneous administration of the juvenile hormone mimic methoprene. Larvae simultaneously treated with both hormone mimics continued to grow until they attained a size about three times normal. This growth was accompanied by at least one and sometimes two supernumerary molts, whereas, only an occasional supernumerary molt occurred in larvae treated with methoprene alone. In larvae undergoing super numerary molts, wing imaginal discs produced a tanned pupal cuticle, but did not evaginate. When wing discs were cultured in vitro, RH 5849 stimulated evagination and chitin synthesis at concentrations of 10 and 1 μM, respectively. Likewise, RH 5849 stimulated GlcNAc uptake and inhibited cellular proliferation in IAL-PID2 cells at similar concentrations. These in vitro effects of RH 5849 also were produced by 20-hydroxyecdysone, but at lower concentrations. We conclude that RH 5849 exhibits molting hormone activity in vivo as well as in vitro. However, the toxicological effects in P. interpuncetella result from action on feeding and growth, rather than molting. Thus, RH 5849 represents a new class of IGR, which will have impact on our understanding of endocrine regulation and open up new avenues for pest control.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940150402
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  • 2
    Electronic Resource
    Electronic Resource
    Benzoylphenyl ureas inhibit chitin synthesis without interfering with amino sugar uptake in imaginal wing discs of Plodia interpunctella (Hübner) (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Archives of Insect Biochemistry and Physiology 18 (1991), S. 219-227 
    Details
    ISSN: 0739-4462
    Keywords: ecdysteroids ; diflubenzuron ; teflubenzuron ; N-acetylglucosamine ; Indian meal moth ; Chemistry ; Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We tested the hypothesis that the inhibition of chitin synthesis by benzoylphenyl ureas could be explained by their effect on the uptake of GlcNAc into chitin. Our test system consisted of organ cultures of wing imaginal discs from Plodia interpunctella. These wing discs synthesize chitin in response to 20-hydroxyecdysone or RH 5849, a non-steroidal ecdysteroid mimic. Two benzoylphenyl ureas, diflubenzuron and teflubenzuron, inhibited ecdysteroid-dependent chitin synthesis in the wing discs. However, although chitin synthesis was inhibited, there was no corresponding diminution of amino sugar uptake by the imaginal discs. In another experiment 20-hydroxyecdysone stimulated uptake of two sugars, 2-deoxy-D-glucose and 3-O-methyl-D-glucose, which are not synthesized into chitin. Transport of these non-metabolized sugars was unaffected by the inhibitors. In an additional test of the effects on precursor transport, the action of ecdysone (alpha-ecdysone) was examined. Ecdysone stimulated amino sugar uptake, but not chitin synthesis. Neither diflubenzuron nor teflubenzuron inhibited ecdysone-dependent precursor transport. Finally, we examined ecdysteroid-induced uptake of amino sugars by an imaginal disc derived cell line IAL-PID2. In this case, also, GlcNAc transport was not inhibited significantly by either diflubenzuron or teflubenzuron. From these observations we conclude that inhibition of uptake of amino sugars does not account for the ability of teflubenzuron and diflubenzuron to inhibit chitin synthesis in P. interpunctella wing discs.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/arch.940180404
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