Publication Date:
2013-01-19
Description:
There have been substantial advances in cancer diagnostics and therapies in the past decade. Besides chemotherapeutic agents and radiation therapy, approaches now include targeting cancer cell-intrinsic mediators linked to genetic aberrations in cancer cells, in addition to cancer cell-extrinsic pathways, especially those regulating vascular programming of solid tumors. More recently, immunotherapeutics have entered the clinic largely on the basis of the recognition that several immune cell subsets, when chronically activated, foster tumor development. Here, we discuss clinical and experimental studies delineating protumorigenic roles for immune cell subsets that are players in cancer-associated inflammation. Some of these cells can be targeted to reprogram their function, leading to resolution, or at least neutralization, of cancer-promoting chronic inflammation, thereby facilitating cancer rejection.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591506/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591506/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Coussens, Lisa M -- Zitvogel, Laurence -- Palucka, A Karolina -- R01 CA155331/CA/NCI NIH HHS/ -- U54 CA163123/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2013 Jan 18;339(6117):286-91. doi: 10.1126/science.1232227.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cell and Developmental Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR 97239-3098, USA. coussenl@ohsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23329041" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies/therapeutic use
;
Breast Neoplasms/immunology/pathology
;
Carcinoma, Ductal/immunology/pathology
;
Chemokines/antagonists & inhibitors/immunology
;
Chronic Disease
;
Cytokines/antagonists & inhibitors/immunology
;
Disease Progression
;
Female
;
Humans
;
Immunotherapy/*methods
;
Inflammation/*immunology/pathology/*therapy
;
Leukocytes/*immunology
;
Myeloid Cells/immunology
;
Neoplasms/*immunology/pathology/*therapy
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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