ISSN:
0570-0833
Keywords:
Nucleosides
;
Nucleotides
;
Antiviral agents
;
Immunochemistry
;
Chemistry
;
General Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The present article summarizes recent progress in the study of nucleoside derivatives as antiviral and immunosuppressive agents. A number of 5′-substituted 5′-deoxy nucleosides have been found to be permeable and nonincorporable antimetabolites of 5′-nucleotides. N6-isopentenyladenosine and analogs show certain promising immunosuppressive activities. Encouraged by the antibody-stimulating effect of oligonucleotides, we have developed a convenient synthesis of oligonucleotides using fully protected phosphorylated intermediates. A group of tetradeoxyribonucleotides, dApdApdApdX, was prepared for biological and physical evaluations. Nucleotide derivatives may prove valuable in the treatment of several immunological disorders.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/anie.197006781
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