Publication Date:
2011-03-26
Description:
Understanding how the immune system affects cancer development and progression has been one of the most challenging questions in immunology. Research over the past two decades has helped explain why the answer to this question has evaded us for so long. We now appreciate that the immune system plays a dual role in cancer: It can not only suppress tumor growth by destroying cancer cells or inhibiting their outgrowth but also promote tumor progression either by selecting for tumor cells that are more fit to survive in an immunocompetent host or by establishing conditions within the tumor microenvironment that facilitate tumor outgrowth. Here, we discuss a unifying conceptual framework called "cancer immunoediting," which integrates the immune system's dual host-protective and tumor-promoting roles.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schreiber, Robert D -- Old, Lloyd J -- Smyth, Mark J -- New York, N.Y. -- Science. 2011 Mar 25;331(6024):1565-70. doi: 10.1126/science.1203486.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA. schreiber@immunology.wustl.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21436444" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptive Immunity
;
Animals
;
Antigens, Neoplasm/immunology
;
Humans
;
Immune System/*physiology
;
Immune Tolerance
;
Immunity, Innate
;
Immunocompromised Host
;
Immunologic Surveillance
;
Immunotherapy
;
Lymphocytes, Tumor-Infiltrating/immunology
;
Mice
;
Models, Immunological
;
Neoplasms/*immunology/therapy
;
Prognosis
;
Tumor Escape
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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