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  • 1
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    Emerging challenges in regulatory T cell function and biology (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2007-08-04
    Description: Much progress has been made in understanding how the immune system is regulated, with a great deal of recent interest in naturally occurring CD4+ regulatory T cells that actively engage in the maintenance of immunological self-tolerance and immune homeostasis. The challenge ahead for immunologists is the further elucidation of the molecular and cellular processes that govern the development and function of these cells. From this, exciting possibilities are emerging for the manipulation of regulatory T cell pathways in treating immunological diseases and suppressing or augmenting physiological immune responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sakaguchi, Shimon -- Powrie, Fiona -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2007 Aug 3;317(5838):627-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto 606-8507, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17673654" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen-Presenting Cells/immunology ; Antigens/immunology ; Autoimmune Diseases/immunology ; Forkhead Transcription Factors/metabolism ; Homeostasis ; Humans ; Immune Tolerance ; Infection/immunology ; Inflammation/immunology ; Lymphocyte Activation ; Mice ; Self Tolerance ; T-Lymphocytes/immunology ; T-Lymphocytes, Regulatory/*immunology/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Immunology. Regulating the regulators (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-02-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Powrie, Fiona -- Maloy, Kevin J -- New York, N.Y. -- Science. 2003 Feb 14;299(5609):1030-1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK. fiona.powrie@path. ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12586934" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen Presentation ; Antigen-Presenting Cells/immunology ; Autoimmune Diseases/immunology/prevention & control ; Cell Differentiation ; DNA-Binding Proteins/genetics/*metabolism ; Dendritic Cells/*immunology ; *Drosophila Proteins ; Forkhead Transcription Factors ; Graft Rejection/immunology ; Humans ; Immune Tolerance ; Immunity, Innate ; Interleukin-10/immunology ; Interleukin-6/immunology/secretion ; Lymphocyte Activation ; Membrane Glycoproteins/*physiology ; Mice ; Models, Immunological ; Mutation ; Receptors, Cell Surface/*physiology ; Receptors, Interleukin-2/analysis ; Signal Transduction ; T-Lymphocyte Subsets/*immunology ; T-Lymphocytes, Regulatory/*immunology ; Thymus Gland/cytology/immunology ; Toll-Like Receptors ; Transduction, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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