ISSN:
1432-1041
Keywords:
Hypertension
;
α2-Adrenoceptors
;
Yohimbine
;
plasma catecholamines
;
α1-adrenoceptors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary We have studied the sympathetic response to blockade of presynaptic α2-adrenoceptors in essential hypertension by measuring plasma concentrations of noradrenaline after a single oral dose of yohimbine, an α2-adrenoceptor antagonist. Mean baseline plasma noradrenaline and adrenaline concentrations were similar in the hypertensive and normotensive groups. Yohimbine (0.2 mg×kg−1 orally) caused a lesser increase in the plasma concentrations of noradrenaline in hypertensive patients (+67%) than in normotensive subjects (+178%) and a pressor response in hypertensive (but not in normotensive) patients. These results are consistent with an alteration in the balance of α-adrenoceptors (for example presynaptic α2-adrenoceptor desensitization and post-synaptic α1-adrenoceptor hyper-responsiveness) which would help to develop and/or maintain arterial hypertension.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00315481
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