ISSN:
1572-8854
Keywords:
Hydrogen bonding
;
1,4-dihydropyridine
;
calcium beta blockers
;
single crystal structures
Source:
Springer Online Journal Archives 1860-2000
Topics:
Geosciences
,
Physics
Notes:
Abstract Hydrogen bonding interactions displayed by three crystalline chloro-substituted 4-phenyl-1,4-dihydropyridine molecules 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis(methoxycarbonyl), 4-(2,4-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis (methoxycarbonyl) and 4-(2,3,5-trichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-bis (methoxycarbonyl), suggests that, in contrast to previous observation, sp orientation of the 3 or 5 substituted carbonyl group accomodates hydrogen bonding to the carbonyl oxygen atom when polar orthosubstituents exist on the phenyl ring.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1011904401069
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