Publication Date:
1995-11-24
Description:
The assembly and transport of major histocompatibility complex (MHC) class II molecules require interaction with the invariant chain. A fragment of the invariant chain, CLIP, occupies the peptide-binding groove of the class II molecule. At endosomal pH, the binding of CLIP to human MHC class II HLA-DR molecules was counteracted by its amino-terminal segment (residues 81 to 89), which facilitated rapid release. The CLIP (81-89) fragment also catalyzed the release of CLIP(90-105) and a subset of other self-peptides, probably by transient interaction with an effector site outside the groove. Thus, CLIP may facilitate peptide loading through an allosteric release mechanism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kropshofer, H -- Vogt, A B -- Stern, L J -- Hammerling, G J -- New York, N.Y. -- Science. 1995 Nov 24;270(5240):1357-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Immunology, German Cancer Research Center, Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7481823" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Antigens, Differentiation, B-Lymphocyte/chemistry/*metabolism
;
Binding Sites
;
Cell Line
;
HLA-DR3 Antigen/*metabolism
;
Histocompatibility Antigens Class II/chemistry/*metabolism
;
Humans
;
Hydrogen-Ion Concentration
;
Lysine/chemistry
;
Molecular Sequence Data
;
Peptide Fragments/metabolism
;
Proline/chemistry
;
Protein Conformation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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