ISSN:
1432-0878
Keywords:
Carotid body
;
Calcitonin
;
Calcitonin mRNA
;
Gene expression
;
Oligonucleotide probe
;
In situ hybridization
;
Human
;
Monkey, Macaca fascicularis (Primates)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Calcitonin mRNA was detected in human and monkey carotid bodies by in situ hybridization histochemistry, using a 35S-labeled oligonucleotide probe for human calcitonin. In both human and monkey carotid body, moderate to high hybridization signal for calcitonin mRNA was observed in all cases. The hybridization signal in the formalin-fixed, paraffin-embedded samples was comparable to that obtained from frozen paraformaldehyde-fixed tissue. Our observations extend the finding of calcitonin-like immunoreactivity in the carotid body chief cells and indicate that calcitonin is produced in the carotid body, probably in the chief cells.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00306125
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