Publication Date:
2010-04-17
Description:
Minzenberg et al. (Reports, 12 December 2008, p. 1700) and Schmidt et al. (Reports, 24 April 2009, p. 516) reported blood oxygen level-dependent (BOLD) responses in the human locus coeruleus (LC). Here, we show that these LC responses do not correspond to the anatomical location of the LC and present cautionary data concerning the quality of BOLD signals measured from the LC using standard functional magnetic resonance imaging acquisition parameters.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704136/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3704136/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Astafiev, Serguei V -- Snyder, Abraham Z -- Shulman, Gordon L -- Corbetta, Maurizio -- R01 MH071920/MH/NIMH NIH HHS/ -- R01 MH71920-06/MH/NIMH NIH HHS/ -- R01 NS048013/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2010 Apr 16;328(5976):309; author reply 309. doi: 10.1126/science.1177200.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Radiology, Washington University in St. Louis, Box 8225, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20395497" target="_blank"〉PubMed〈/a〉
Keywords:
Attention
;
Benzhydryl Compounds/pharmacology
;
Brain Mapping
;
Brain Stem/anatomy & histology
;
Central Nervous System Stimulants/pharmacology
;
Homeostasis
;
Humans
;
Locus Coeruleus/*anatomy & histology/drug effects/*physiology
;
Magnetic Resonance Imaging
;
Melanins/analysis
;
Neurons/drug effects/physiology
;
Oxygen/blood
;
Sleep
;
Suprachiasmatic Nucleus/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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