Publication Date:
1998-08-07
Description:
The two lineages of T cells, alphabeta and gammadelta, differ in their developmental requirements: only alphabeta T cells require major histocompatibility complex recognition, a process known as positive selection. The alphabeta T cell receptor (TCR), but not its gammadelta counterpart, contains a motif within the alpha-chain connecting peptide domain (alpha-CPM) that has been conserved over the last 500 million years. In transgenic mice expressing an alphabeta TCR lacking the alpha-CPM, thymocytes were blocked in positive selection but could undergo negative selection. Thus, the alpha-CPM seems to participate in the generation of signals required for positive selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Backstrom, B T -- Muller, U -- Hausmann, B -- Palmer, E -- New York, N.Y. -- Science. 1998 Aug 7;281(5378):835-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Basel Institute for Immunology, CH-4005 Basel, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9694657" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Animals
;
Antigen-Presenting Cells/immunology
;
Antigens, CD3/analysis
;
CD4-Positive T-Lymphocytes/immunology
;
Cell Lineage
;
Cells, Cultured
;
Histocompatibility Antigens Class II/immunology
;
Ligands
;
Lymphocyte Count
;
Membrane Proteins/analysis
;
Mice
;
Mice, Inbred C57BL
;
Mice, Nude
;
Mice, Transgenic
;
Molecular Sequence Data
;
Mutation
;
Receptor-CD3 Complex, Antigen, T-Cell/immunology/metabolism
;
Receptors, Antigen, T-Cell/analysis
;
Receptors, Antigen, T-Cell, alpha-beta/*chemistry/genetics/*immunology
;
Signal Transduction
;
T-Lymphocyte Subsets/*immunology
;
Thymus Gland/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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