Publication Date:
1992-08-07
Description:
In vitro, when the B7 molecule on the surface of antigen-presenting cells binds to the T cell surface molecules CD28 and CTLA-4, a costimulatory signal for T cell activation is generated. CTLA4Ig is a soluble form of the extracellular domain of CTLA-4 and binds B7 with high avidity. CTLA4Ig treatment in vivo suppressed T cell-dependent antibody responses to sheep erythrocytes or keyhole limpet hemocyanin. Large doses of CTLA4Ig suppressed responses to a second immunization. Thus, costimulation by B7 is important for humoral immune responses in vivo, and interference with costimulation may be useful for treatment of antibody-mediated autoimmune disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linsley, P S -- Wallace, P M -- Johnson, J -- Gibson, M G -- Greene, J L -- Ledbetter, J A -- Singh, C -- Tepper, M A -- New York, N.Y. -- Science. 1992 Aug 7;257(5071):792-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, WA 98121.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1496399" target="_blank"〉PubMed〈/a〉
Keywords:
Abatacept
;
Animals
;
Antibody Formation/*drug effects
;
Antigens, CD
;
Antigens, Differentiation/*immunology/metabolism
;
CHO Cells
;
CTLA-4 Antigen
;
Cricetinae
;
Erythrocytes/immunology
;
Hemocyanin/immunology
;
Humans
;
Immunization
;
*Immunoconjugates
;
Immunosuppressive Agents/pharmacokinetics/*pharmacology
;
Lymphocyte Activation
;
Metabolic Clearance Rate
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred Strains
;
Recombinant Fusion Proteins/pharmacokinetics/pharmacology
;
T-Lymphocytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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