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  • circular dichroism  (2)
  • HMG-CoA reductase inhibitor  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Ultraviolet (UV) Absorption and Circular Dichroism (CD) Spectra of Captopril (1990)
    Springer
    Pharmaceutical research 7 (1990), S. 1082-1085 
    Details
    ISSN: 1573-904X
    Keywords: captopril ; ultraviolet absorption ; circular dichroism ; spectra ; diastereomers ; chirality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The ultraviolet and circular dichroism spectra of authentic captopril have been obtained, since the reported literature data are inconsistent with those obtained on highly purified material. The UV absorption spectrum consists of a single band maximum at 200 nm, while the CD spectrum consists of a single negative peak located at 210 nm. The CD spectrum of captopril and its other three diastereomers can be explained largely in terms of a summation of the chirality of its individual components, (S)-proline and (2S)-3-mercapto-2-methylpropionic acid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015907620546
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of Humidity-Dependent Changes in Crystal Structure on the Solid-State Fluorescence Properties of a New HMG-CoA Reductase Inhibitor (1995)
    Springer
    Pharmaceutical research 12 (1995), S. 556-559 
    Details
    ISSN: 1573-904X
    Keywords: HMG-CoA reductase inhibitor ; SQ-33600 ; crystal structure ; hydrates ; solid-state fluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract It has been shown previously that the disodium salt of a new HMG-CoA reductase inhibitor (SQ-33600) is capable of existing as a number of hydrate species [1]. Three crystalline solid hydrates and one liquid crystalline phase have been identified, each having a definite stability over a defined range of humidity. These forms have been found to exhibit varying fluorescence properties in their respective solid states, with differences in bandshapes and intensities being noted for each. These spectral variations have been correlated with the known pseudopolymorphism of the compound.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016206130213
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  • 3
    Electronic Resource
    Electronic Resource
    Circular dichroism studies of the self-association of amphotericin B (1994)
    New York, NY [u.a.] : Wiley-Blackwell
    Chirality 6 (1994), S. 665-669 
    Details
    ISSN: 0899-0042
    Keywords: circular dichroism ; amphotericin B ; self-association ; manomer/oligomer ; solvent effects ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Circular dichroism (CD) spectroscopy has been used to evaluate the ability of 21 different solvents to influence the aggregation state of amphotericin B. Using the relative donor/acceptor tendencies known for each solvent system, it was possible to deduce information as to the factors which goven the self-association of amphotericin B. It was concluded that in the absence of strong solvent interaction, amphotericin B prefers to self-associate into oligomeric species. This intrinsic driving force can be overcome through the use of solvents which function as strong electron pair donors, probably forming specific solvent - solute species. © 1994 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/chir.530060811
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