Publication Date:
1986-04-18
Description:
T-cell receptors bind antigens only when the antigens are exposed on the cell surface. This can be studied best in the interaction of cytolytic T lymphocytes (CTL) with target cells because the recognition and binding event can be separated from the lytic phase. Studies with CTL clones specific for HLA-A2 and HLA-B7 demonstrated that conjugates of CTL's and target cells can be formed in the absence of specific antigen recognition. Furthermore, T-cell receptor and target antigen cannot interact unless there is conjugate formation. This indicates that nonspecific conjugate formation between CTL's and target cells precedes the recognition of specific antigen by the T-cell receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spits, H -- van Schooten, W -- Keizer, H -- van Seventer, G -- van de Rijn, M -- Terhorst, C -- de Vries, J E -- AI-15066/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1986 Apr 18;232(4748):403-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3485822" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Monoclonal/immunology
;
Cell Adhesion
;
Clone Cells
;
HLA Antigens/immunology
;
HLA-A2 Antigen
;
HLA-B7 Antigen
;
Humans
;
Isoantigens/*immunology
;
Receptors, Antigen, T-Cell/immunology
;
T-Lymphocytes, Cytotoxic/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
