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  • 1
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    Benefits and risks of influenza research: lessons learned (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: Given the yearly challenge of seasonal influenza and the potential catastrophic consequences of future pandemics, the need for intensive basic and clinical influenza research is unquestionable. Although the fruits of decades of research have enabled dramatic improvements in our ability to prevent and treat influenza, many fundamental questions remain, including those related to the complex factors associated with host switching and transmission of influenza viruses. Recent public concern over two H5N1 influenza manuscripts that studied the transmissibility of influenza viruses has triggered intense discussion on dual-use research and the way forward.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Collins, Francis S -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1522-3. doi: 10.1126/science.1224305.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA. afauci@niaid.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723407" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; *Biomedical Research ; Bioterrorism ; Disease Models, Animal ; Evolution, Molecular ; Ferrets ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza, Human/mortality/transmission/*virology ; Mutation ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission/*virology ; Public Health ; Public Policy ; *Publishing ; Reassortant Viruses/genetics/pathogenicity ; Risk Assessment ; Security Measures ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Medicine. The need for a global HIV vaccine enterprise (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-06-28
    Description: A new collaborative model of research is needed to increase resources, to prioritize the R (ii) to increase the pace, reduce the overlap, and more systematically explore the elements of and delivery systems for vaccines; (iii) to use common standards for the prompt comparative testing of vaccine candidates; (iv) to expand resources for manufacturing vaccine candidates to speed their use in human trials; and (v) to increase the capacity for international clinical trials and to focus this effort toward quickly measuring the effectiveness of vaccine protection as prototype vaccine candidates are identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klausner, Richard D -- Fauci, Anthony S -- Corey, Lawrence -- Nabel, Gary J -- Gayle, Helene -- Berkley, Seth -- Haynes, Barton F -- Baltimore, David -- Collins, Chris -- Douglas, R Gordon -- Esparza, Jose -- Francis, Donald P -- Ganguly, N K -- Gerberding, Julie Louise -- Johnston, Margaret I -- Kazatchkine, Michel D -- McMichael, Andrew J -- Makgoba, Malegapuru W -- Pantaleo, Giuseppe -- Piot, Peter -- Shao, Yiming -- Tramont, Edmund -- Varmus, Harold -- Wasserheit, Judith N -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2036-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bill and Melinda Gates Foundation, Seattle, WA 98102, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12829768" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines/administration & dosage/economics/immunology ; Academies and Institutes/economics/organization & administration ; Biotechnology/economics ; Clinical Trials as Topic/standards ; Drug Design ; Drug Evaluation, Preclinical/standards ; Drug Industry/economics ; Financial Support ; *Global Health ; HIV Infections/*prevention & control ; HIV-1/*immunology ; Humans ; Intellectual Property ; International Cooperation ; Multicenter Studies as Topic ; Private Sector ; *Public Policy ; Public Sector ; Research Support as Topic ; Vaccination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    NIH response to open letter (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Zerhouni, Elias A -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):49.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802584" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Warfare ; *Biomedical Research/economics ; *Bioterrorism ; Budgets ; Financing, Government ; *Microbiology ; *National Institutes of Health (U.S.) ; Peer Review, Research ; Public Health ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Immunology. Immune activation with HIV vaccines (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2014-04-05
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414116/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4414116/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Marovich, Mary A -- Dieffenbach, Carl W -- Hunter, Eric -- Buchbinder, Susan P -- P51 OD011132/OD/NIH HHS/ -- P51 RR000165/RR/NCRR NIH HHS/ -- U19 AI096187/AI/NIAID NIH HHS/ -- UM1 AI068614/AI/NIAID NIH HHS/ -- Z01 AI000390-25/Intramural NIH HHS/ -- Z01 AI000677-15/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Apr 4;344(6179):49-51. doi: 10.1126/science.1250672.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24700849" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/*administration & dosage/*immunology/*therapeutic use ; Female ; HIV Antigens/*immunology ; HIV Infections/*immunology/*prevention & control ; HIV-1/*immunology ; Humans ; Male ; T-Lymphocytes/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    HIV vaccine research: the way forward (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-07-26
    Description: The need to broaden research directed at answering fundamental questions in HIV vaccine discovery through laboratory, nonhuman primate (NHP), and clinical research has recently been emphasized. In addition, the importance of attracting and retaining young researchers, developing better NHP models, and more closely linking NHP and clinical research is being stressed. In an era of a level budget for biomedical research at the U.S. National Institutes of Health (NIH), HIV/AIDS vaccine research efforts will need to be carefully prioritized such that resources to energize HIV vaccine discovery can be identified. This article summarizes progress and challenges in HIV vaccine research, the priorities arising from a recent summit at NIAID, and the actions needed, some already under way, to address those priorities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Johnston, Margaret I -- Dieffenbach, Carl W -- Burton, Dennis R -- Hammer, Scott M -- Hoxie, James A -- Martin, Malcolm -- Overbaugh, Julie -- Watkins, David I -- Mahmoud, Adel -- Greene, Warner C -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2008 Jul 25;321(5888):530-2. doi: 10.1126/science.1161000.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Allergy and Infectious Diseases, National Institutes of Health, 31 Center Drive, Bethesda, MD 20892, USA. afauci@niaid.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18653883" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines/economics/immunology ; Animals ; *Biomedical Research/economics ; Controlled Clinical Trials as Topic ; Disease Models, Animal ; Financing, Government ; HIV/immunology/physiology ; HIV Antibodies/immunology ; HIV Infections/immunology/*prevention & control/virology ; Humans ; Male ; National Institute of Allergy and Infectious Diseases (U.S.)/economics ; Primates ; Research Support as Topic ; T-Lymphocytes/immunology ; United States ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    NIH research: think globally (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-04-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Collins, Francis S -- New York, N.Y. -- Science. 2015 Apr 10;348(6231):159. doi: 10.1126/science.aab2733.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Anthony S. Fauci is director of the U.S. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. afauci@niad.nih.gov. ; Francis S. Collins is director of the U.S. National Institutes of Health, Bethesda, MD. collinsf@mail.nih.gov.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25859018" target="_blank"〉PubMed〈/a〉
    Keywords: *Biomedical Research/economics/organization & administration ; Financing, Government ; *Global Health ; *National Institutes of Health (U.S.)/economics/organization & administration ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    PUBLIC HEALTH. Toward an HIV vaccine: A scientific journey (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-07-25
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Marston, Hilary D -- New York, N.Y. -- Science. 2015 Jul 24;349(6246):386-7. doi: 10.1126/science.aac6300. Epub 2015 Jul 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Anthony S. Fauci M.D. is the Director of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health, Bethesda, MD 20892, USA. afauci@niaid.nih.gov. ; Hilary D. Marston M.D., M.P.H. is a Medical Officer and Policy Advisor for Global Health at the National Institute of Allergy and Infectious Diseases at the National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26206922" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/administration & dosage/chemistry/*immunology ; Antibodies, Neutralizing/chemistry/*immunology ; CD8-Positive T-Lymphocytes/*immunology ; *Drug Design ; Epitopes/immunology ; HIV Envelope Protein gp160/immunology ; HIV Envelope Protein gp41/immunology ; HIV Infections/prevention & control/*therapy ; HIV-1/*immunology ; Humans
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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