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  • 1
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    Anopheles gambiae genome: completing the malaria triad (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-05
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aultman, Kathryn S -- Gottlieb, Michael -- Giovanni, Maria Y -- Fauci, Anthony S -- New York, N.Y. -- Science. 2002 Oct 4;298(5591):13.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12364752" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anopheles/*genetics ; Genes, Insect ; *Genome ; Genome, Human ; Genome, Protozoan ; Haplotypes ; Humans ; Insect Vectors/*genetics ; Malaria, Falciparum/epidemiology/transmission ; Plasmodium falciparum/genetics ; Polymorphism, Genetic ; Private Sector ; Public Sector ; Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    25 years of HIV (2008)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2008-05-16
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- England -- Nature. 2008 May 15;453(7193):289-90. doi: 10.1038/453289a.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute of Allergy and Infectious Diseases (NIAID) at the US National Institutes of Health in Bethesda, Maryland, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18480799" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS Vaccines/history ; Anti-HIV Agents/history/supply & distribution/therapeutic use ; Drug Resistance, Viral ; HIV/drug effects/genetics/isolation & purification/physiology ; HIV Infections/drug therapy/*history/prevention & control/virology ; History, 20th Century ; History, 21st Century ; Humans ; Time Factors ; Zidovudine/history/pharmacology/therapeutic use
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 3
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    The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4 (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-07-21
    Description: Human immunodeficiency virus type 1 (HIV-1) selectively infects cells expressing the CD4 molecule, resulting in substantial quantitative and qualitative defects in CD4+ T lymphocyte function in patients with acquired immunodeficiency syndrome (AIDS). However, only a very small number of cells in the peripheral blood of HIV-1-infected individuals are expressing virus at any given time. Previous studies have demonstrated that in vitro infection of CD4+ T cells with HIV-1 results in downregulation of CD4 expression such that CD4 protein is no longer detectable on the surface of the infected cells. In the present study, highly purified subpopulations of peripheral blood mononuclear cells (PBMCs) from AIDS patients were obtained and purified by fluorescence-automated cell sorting. They were examined with the methodologies of virus isolation by limiting dilution analysis, in situ hybridization, immunofluorescence, and gene amplification. Within PBMCs, HIV-1 was expressed in vivo predominantly in the T cell subpopulation which, in contrast to the in vitro observations, continued to express CD4. The precursor frequency of these HIV-1-expressing cells was about 1/1000 CD4+ T cells. The CD4+ T cell population contained HIV-1 DNA in all HIV-1-infected individuals studied and the frequency in AIDS patients was at least 1/100 cells. This high level of infection may be the primary cause for the progressive decline in number and function of CD4+ T cells in patients with AIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schnittman, S M -- Psallidopoulos, M C -- Lane, H C -- Thompson, L -- Baseler, M -- Massari, F -- Fox, C H -- Salzman, N P -- Fauci, A S -- N01-CO-74102/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1989 Jul 21;245(4915):305-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2665081" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/*immunology/microbiology ; Antigens, Differentiation, T-Lymphocyte/*immunology ; Cell Separation ; DNA, Viral/analysis ; Flow Cytometry ; Fluorescent Antibody Technique ; Gene Amplification ; HIV-1/genetics/*physiology ; Humans ; Nucleic Acid Hybridization ; RNA, Viral/analysis ; T-Lymphocytes/immunology/*microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Twenty-five years of HIV/AIDS (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-07-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- New York, N.Y. -- Science. 2006 Jul 28;313(5786):409.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16873613" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome/drug therapy/epidemiology/prevention & ; control/virology ; Anti-HIV Agents/therapeutic use ; Biomedical Research/economics ; Delivery of Health Care ; Disease Outbreaks ; Female ; Global Health ; HIV Infections/drug therapy/epidemiology/prevention & control/virology ; Health Services Accessibility ; Humans ; Male
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Immunology. Salmonella susceptibility (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-04-24
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Moir, Susan -- Fauci, Anthony S -- New York, N.Y. -- Science. 2010 Apr 23;328(5977):439-40. doi: 10.1126/science.1189088.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. smoir@niaid.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20413482" target="_blank"〉PubMed〈/a〉
    Keywords: AIDS-Related Opportunistic Infections/immunology ; Animals ; Antibodies, Bacterial/blood/*immunology ; Antibodies, Blocking/blood/*immunology ; Bacteremia/immunology ; Bacterial Outer Membrane Proteins/immunology ; Disease Susceptibility ; HIV Infections/complications/*immunology ; Humans ; Lipopolysaccharides/blood/*immunology ; Mice ; Salmonella/*immunology ; Salmonella Infections/*immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    AIDS: let science inform policy (2011)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2011-07-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- New York, N.Y. -- Science. 2011 Jul 1;333(6038):13. doi: 10.1126/science.1209751.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21719646" target="_blank"〉PubMed〈/a〉
    Keywords: *Acquired Immunodeficiency Syndrome/drug ; therapy/economics/epidemiology/prevention & control ; Anti-HIV Agents/therapeutic use ; Biomedical Research ; Female ; Global Health ; Health Expenditures ; *Health Policy/economics ; Humans ; Male ; Pandemics/prevention & control
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Benefits and risks of influenza research: lessons learned (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-06-23
    Description: Given the yearly challenge of seasonal influenza and the potential catastrophic consequences of future pandemics, the need for intensive basic and clinical influenza research is unquestionable. Although the fruits of decades of research have enabled dramatic improvements in our ability to prevent and treat influenza, many fundamental questions remain, including those related to the complex factors associated with host switching and transmission of influenza viruses. Recent public concern over two H5N1 influenza manuscripts that studied the transmissibility of influenza viruses has triggered intense discussion on dual-use research and the way forward.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Collins, Francis S -- New York, N.Y. -- Science. 2012 Jun 22;336(6088):1522-3. doi: 10.1126/science.1224305.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA. afauci@niaid.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22723407" target="_blank"〉PubMed〈/a〉
    Keywords: Advisory Committees ; Animals ; *Biomedical Research ; Bioterrorism ; Disease Models, Animal ; Evolution, Molecular ; Ferrets ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity ; Influenza, Human/mortality/transmission/*virology ; Mutation ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission/*virology ; Public Health ; Public Policy ; *Publishing ; Reassortant Viruses/genetics/pathogenicity ; Risk Assessment ; Security Measures ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Research funding. A framework for decisions about research with HPAI H5N1 viruses (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-02-23
    Description: 〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011183/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4011183/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patterson, Amy P -- Tabak, Lawrence A -- Fauci, Anthony S -- Collins, Francis S -- Howard, Sally -- Z99 AI999999/Intramural NIH HHS/ -- Z99 OD999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2013 Mar 1;339(6123):1036-7. doi: 10.1126/science.1236194. Epub 2013 Feb 21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institutes of Health, Bethesda, MD 20892, USA. pattersa@od.nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23429700" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biomedical Research/*education ; Birds ; Guidelines as Topic ; Humans ; Influenza A Virus, H5N1 Subtype/genetics/*pathogenicity ; Influenza in Birds/*transmission ; Influenza, Human/*transmission ; Safety
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Medicine. The need for a global HIV vaccine enterprise (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-06-28
    Description: A new collaborative model of research is needed to increase resources, to prioritize the R (ii) to increase the pace, reduce the overlap, and more systematically explore the elements of and delivery systems for vaccines; (iii) to use common standards for the prompt comparative testing of vaccine candidates; (iv) to expand resources for manufacturing vaccine candidates to speed their use in human trials; and (v) to increase the capacity for international clinical trials and to focus this effort toward quickly measuring the effectiveness of vaccine protection as prototype vaccine candidates are identified.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klausner, Richard D -- Fauci, Anthony S -- Corey, Lawrence -- Nabel, Gary J -- Gayle, Helene -- Berkley, Seth -- Haynes, Barton F -- Baltimore, David -- Collins, Chris -- Douglas, R Gordon -- Esparza, Jose -- Francis, Donald P -- Ganguly, N K -- Gerberding, Julie Louise -- Johnston, Margaret I -- Kazatchkine, Michel D -- McMichael, Andrew J -- Makgoba, Malegapuru W -- Pantaleo, Giuseppe -- Piot, Peter -- Shao, Yiming -- Tramont, Edmund -- Varmus, Harold -- Wasserheit, Judith N -- New York, N.Y. -- Science. 2003 Jun 27;300(5628):2036-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Bill and Melinda Gates Foundation, Seattle, WA 98102, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12829768" target="_blank"〉PubMed〈/a〉
    Keywords: *AIDS Vaccines/administration & dosage/economics/immunology ; Academies and Institutes/economics/organization & administration ; Biotechnology/economics ; Clinical Trials as Topic/standards ; Drug Design ; Drug Evaluation, Preclinical/standards ; Drug Industry/economics ; Financial Support ; *Global Health ; HIV Infections/*prevention & control ; HIV-1/*immunology ; Humans ; Intellectual Property ; International Cooperation ; Multicenter Studies as Topic ; Private Sector ; *Public Policy ; Public Sector ; Research Support as Topic ; Vaccination
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    NIH response to open letter (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-04-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fauci, Anthony S -- Zerhouni, Elias A -- New York, N.Y. -- Science. 2005 Apr 1;308(5718):49.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15802584" target="_blank"〉PubMed〈/a〉
    Keywords: Biological Warfare ; *Biomedical Research/economics ; *Bioterrorism ; Budgets ; Financing, Government ; *Microbiology ; *National Institutes of Health (U.S.) ; Peer Review, Research ; Public Health ; *Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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