ISSN:
1573-8221
Keywords:
Radioprotectors
;
cyclic AMP system
;
protein kinases
;
phosphorylation of proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The ability of radioprotectors (serotonin, aminoethylisothiouronium) in radioprotective doses to stimulate cyclic AMP-dependent phosphorylation of mouse liver cytosol and nuclear and spleen cytosol proteins in vivo was demonstrated. In experiments in vitro, the radioprotectors had no direct action on protein kinase activity or its stimulation by cyclic AMP. It is postulated on the basis of these results and those of previous investigations that activation of cyclic AMP-dependent phosphorylation is due to an increase in the intracellular cyclic AMP concentration under the influence of the radioprotectors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00801781
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