Publication Date:
1985-09-06
Description:
Gonadotropin-releasing hormone analogs can cause regression of hormone-dependent breast carcinomas. These effects are thought to be mediated through the inhibition of gonadotropic and steroid hormones. These analogs may also act directly on the tumor because they are effective in treating breast cancer in some postmenopausal women. The presence of specific binding sites for gonadotropin-releasing hormone was demonstrated in human breast carcinomas by means of a novel approach of ligand immunoblotting. The results indicate a possible mechanism by which the peptide has direct effects on this tissue. These binding proteins were not detectable in non-neoplastic breast tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Eidne, K A -- Flanagan, C A -- Millar, R P -- New York, N.Y. -- Science. 1985 Sep 6;229(4717):989-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992093" target="_blank"〉PubMed〈/a〉
Keywords:
Adult
;
Breast Neoplasms/*metabolism
;
Female
;
Gonadotropin-Releasing Hormone/*metabolism
;
Humans
;
Membrane Proteins/metabolism
;
Menopause
;
Middle Aged
;
Molecular Weight
;
Receptors, Cell Surface/*metabolism
;
Receptors, LHRH
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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