Publication Date:
2008-06-21
Description:
Specialized secretion systems are used by many bacteria to deliver effector proteins into host cells that can either mimic or disrupt the function of eukaryotic factors. We found that the intracellular pathogens Legionella pneumophila and Coxiella burnetii use a type IV secretion system to deliver into eukaryotic cells a large number of different bacterial proteins containing ankyrin repeat homology domains called Anks. The L. pneumophila AnkX protein prevented microtubule-dependent vesicular transport to interfere with fusion of the L. pneumophila-containing vacuole with late endosomes after infection of macrophages, which demonstrates that Ank proteins have effector functions important for bacterial infection of eukaryotic host cells.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2514061/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2514061/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pan, Xiaoxiao -- Luhrmann, Anja -- Satoh, Ayano -- Laskowski-Arce, Michelle A -- Roy, Craig R -- AG030101/AG/NIA NIH HHS/ -- AI041699/AI/NIAID NIH HHS/ -- AI064559/AI/NIAID NIH HHS/ -- GM060919/GM/NIGMS NIH HHS/ -- R01 AI041699/AI/NIAID NIH HHS/ -- R01 AI041699-12/AI/NIAID NIH HHS/ -- R01 AI064559/AI/NIAID NIH HHS/ -- R01 AI064559-03/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2008 Jun 20;320(5883):1651-4. doi: 10.1126/science.1158160.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18566289" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
*Ankyrin Repeat
;
Bacterial Proteins/*chemistry/genetics/*metabolism
;
CHO Cells
;
Cells, Cultured
;
Coxiella burnetii/*metabolism/pathogenicity
;
Cricetinae
;
Cricetulus
;
Cyclic AMP/metabolism
;
Cytoplasmic Vesicles/metabolism/ultrastructure
;
Cytosol/metabolism
;
Golgi Apparatus/metabolism
;
Humans
;
Intracellular Membranes/metabolism
;
Legionella pneumophila/*metabolism/pathogenicity
;
Microtubules/metabolism
;
Protein Transport
;
Recombinant Fusion Proteins/metabolism
;
Vacuoles/microbiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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