ISSN:
1432-0983
Schlagwort(e):
Kluyveromyces lactis
;
Glucose repression
;
Regulatory genes
;
Yeast
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
Notizen:
Abstract Thefog1 andfog2 mutants of the yeastKluyveromyces lactis were identified by inability to grow on a number of both fermentable and non-fermentable carbon sources. Genetic and physiological evidences suggest a role for FOG1 and FOG2 in the regulation of glucose-repressible gene expression in response to a glucose limitation. The regulatory effect appears to be at the transcriptional level, at least for β-galactosidase. Both genes have been cloned by complementation and sequenced.FOG1 is a unique gene homologous toGAL83, SIP1 andSIP2, a family of regulatory genes affecting glucose repression of the GAL system inSaccharomyces cerevisiae. However, major differences exist betweenfog1 andgal83 mutants.FOG2 is structurally and functionally homologous toSNF1 ofS. cerevisiae and shares withSNF1 a role also in sporulation.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02208612
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