ISSN:
1573-2916
Keywords:
Global optimization
;
Multiple-minima problem
;
Protein folding
;
Structure prediction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Mathematics
Notes:
Abstract Protein folding is a very difficult global optimization problem. Furthermore it is coupled with the difficult task of designing a reliable force field with which one has to search for the global minimum. A summary of a series of optimization methods developed and applied to various problems involving polypeptide chains is described in this paper. With recent developments, a computational treatment of the folding of globular proteins of up to 140 residues is shown to be tractable.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1008328218931
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