Publication Date:
1985-08-30
Description:
The coronavirus, mouse hepatitis virus strain A59 (MHV-A59), causes mild encephalitis and chronic demyelination. Immunohistochemical techniques showed that MHV-A59-infected C57BL/6 mice contained dense deposits of viral antigen in the subthalamic nucleus and substantia nigra, with fewer signs of infection in other regions of the brain. The animals showed extra- and intracellular vacuolation, neuronal loss, and gliosis in the subthalamic-nigral region. Such localization is unprecedented among known viral encephalitides of humans and other species. This infection by a member of a viral class capable of causing both encephalitis and persistent infection in several species may be related to postencephalitic parkinsonism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fishman, P S -- Gass, J S -- Swoveland, P T -- Lavi, E -- Highkin, M K -- Weiss, S R -- New York, N.Y. -- Science. 1985 Aug 30;229(4716):877-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2992088" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Viral/analysis
;
Basal Ganglia/*microbiology
;
Brain/microbiology/pathology
;
Coronaviridae Infections/*microbiology
;
Demyelinating Diseases/microbiology
;
Diencephalon/*microbiology
;
Encephalitis/*microbiology
;
Endoplasmic Reticulum/microbiology
;
Gliosis/microbiology
;
Golgi Apparatus/microbiology
;
Mice
;
Mice, Inbred C57BL
;
*Murine hepatitis virus/immunology
;
Neurons/microbiology/ultrastructure
;
Substantia Nigra/*microbiology
;
Vacuoles/ultrastructure
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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