Publikationsdatum:
1992-03-20
Beschreibung:
The suprachiasmatic nuclei (SCN) of the hypothalamus comprise the primary pacemaker responsible for generation of circadian rhythms in mammals. Light stimuli that synchronize this circadian clock induce expression of the c-fos gene in rodent SCN, which suggests a possible role for Fos in circadian entrainment. Appropriate light stimuli also induce the expression of jun-B messenger RNA in the SCN of golden hamsters but only slightly elevate c-jun messenger RNA levels. In addition, light increases the amount of a protein complex in the SCN that binds specifically to sites on DNA known to mediate regulation by the AP-1 transcription factor. The photic regulation of both jun-B messenger RNA expression and AP-1 binding activity is dependent on circadian phase: only light stimuli that shift behavioral rhythms induce jun-B and AP-1 expression. Thus, light and the circadian pacemaker interact to regulate a specific set of immediate-early genes in the SCN that may participate in entrainment of the circadian clock.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kornhauser, J M -- Nelson, D E -- Mayo, K E -- Takahashi, J S -- New York, N.Y. -- Science. 1992 Mar 20;255(5051):1581-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Neuroscience, Northwestern University, Evanston, IL 60208.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1549784" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
Base Sequence
;
Cricetinae
;
*Gene Expression Regulation
;
Genes, fos/physiology
;
Genes, jun/*physiology
;
*Light
;
Molecular Sequence Data
;
Nucleic Acid Hybridization
;
*Periodicity
;
Proto-Oncogene Proteins c-jun/*biosynthesis
;
RNA Probes
;
RNA, Messenger/*biosynthesis
;
Suprachiasmatic Nucleus/physiology
;
Time Factors
;
Transcription, Genetic
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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