ISSN:
1617-4623
Keywords:
Saccharomyces cerevisiae
;
HOM2 gene
;
Aspartic semi-aldehyde
;
General control
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary In Saccharomyces cerevisiae the HOM2 gene encodes aspartic semi-aldehyde dehydrogenase (ASA DH). The synthesis of this enzyme had been shown to be derepressed by growth in the presence of high concentrations of methionine. In the present work we have cloned and sequenced the HOM2 gene and found that the promoter region of this gene bears one copy of the consensus sequence for general control of amino acid synthesis. This prompted us to study the regulation of the expression of the HOM2 gene. We have found that ASA DH is the first reported enzyme of the related threonine and methionine pathway to be regulated by the general control of amino acid synthesis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00330954
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