Publication Date:
2009-08-25
Description:
Constitutive expression of telomerase in human cells prevents the onset of senescence and crisis by maintaining telomere homeostasis. However, accumulating evidence suggests that the human telomerase reverse transcriptase catalytic subunit (TERT) contributes to cell physiology independently of its ability to elongate telomeres. Here we show that TERT interacts with the RNA component of mitochondrial RNA processing endoribonuclease (RMRP), a gene that is mutated in the inherited pleiotropic syndrome cartilage-hair hypoplasia. Human TERT and RMRP form a distinct ribonucleoprotein complex that has RNA-dependent RNA polymerase (RdRP) activity and produces double-stranded RNAs that can be processed into small interfering RNA in a Dicer (also known as DICER1)-dependent manner. These observations identify a mammalian RdRP composed of TERT in complex with RMRP.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755635/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755635/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maida, Yoshiko -- Yasukawa, Mami -- Furuuchi, Miho -- Lassmann, Timo -- Possemato, Richard -- Okamoto, Naoko -- Kasim, Vivi -- Hayashizaki, Yoshihide -- Hahn, William C -- Masutomi, Kenkichi -- R01 AG023145/AG/NIA NIH HHS/ -- R01 AG023145-05/AG/NIA NIH HHS/ -- R01 AG23145/AG/NIA NIH HHS/ -- England -- Nature. 2009 Sep 10;461(7261):230-5. doi: 10.1038/nature08283. Epub 2009 Aug 23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cancer Stem Cell Project, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19701182" target="_blank"〉PubMed〈/a〉
Keywords:
Cell Line
;
Endoribonucleases/*genetics
;
Gene Expression Regulation
;
HeLa Cells
;
Humans
;
Protein Binding
;
RNA Replicase/*chemistry/*metabolism
;
RNA, Double-Stranded/biosynthesis/genetics/metabolism
;
RNA, Long Noncoding
;
RNA, Small Interfering/biosynthesis/genetics/metabolism
;
RNA, Untranslated/genetics/*metabolism
;
Ribonuclease III/deficiency/genetics/metabolism
;
Ribonucleoproteins/genetics/*metabolism
;
Telomerase/genetics/*metabolism
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
