Publication Date:
2007-01-20
Description:
The Staphylococcus aureus Panton-Valentine leukocidin (PVL) is a pore-forming toxin secreted by strains epidemiologically associated with the current outbreak of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) and with the often-lethal necrotizing pneumonia. To investigate the role of PVL in pulmonary disease, we tested the pathogenicity of clinical isolates, isogenic PVL-negative and PVL-positive S. aureus strains, as well as purified PVL, in a mouse acute pneumonia model. Here we show that PVL is sufficient to cause pneumonia and that the expression of this leukotoxin induces global changes in transcriptional levels of genes encoding secreted and cell wall-anchored staphylococcal proteins, including the lung inflammatory factor staphylococcal protein A (Spa).〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Labandeira-Rey, Maria -- Couzon, Florence -- Boisset, Sandrine -- Brown, Eric L -- Bes, Michele -- Benito, Yvonne -- Barbu, Elena M -- Vazquez, Vanessa -- Hook, Magnus -- Etienne, Jerome -- Vandenesch, Francois -- Bowden, M Gabriela -- AI020624/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2007 Feb 23;315(5815):1130-3. Epub 2007 Jan 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Extracellular Matrix Biology, Institute of Biosciences and Technology, Texas A&M University System Health Science Center, Houston, TX 77030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17234914" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Bacterial Proteins/genetics/metabolism
;
Bacterial Toxins/genetics
;
Calcium-Binding Proteins/genetics/metabolism
;
Disease Models, Animal
;
Exotoxins/genetics/*physiology
;
Gene Expression Profiling
;
Gene Expression Regulation, Bacterial
;
Hemorrhage
;
Leukocidins/genetics/*physiology
;
Lung/microbiology/*pathology
;
Methicillin Resistance
;
Mice
;
Mice, Inbred BALB C
;
Necrosis
;
Oligonucleotide Array Sequence Analysis
;
Pneumonia, Staphylococcal/*microbiology/*pathology
;
Staphylococcal Protein A/genetics/*metabolism
;
Staphylococcus aureus/genetics/growth & development/metabolism/*pathogenicity
;
Transcription, Genetic
;
Virulence
;
Virulence Factors/genetics/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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