ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    facet.materialart.
    Unknown
    Complete genome sequence of a virulent isolate of Streptococcus pneumoniae (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-07-21
    Description: The 2,160,837-base pair genome sequence of an isolate of Streptococcus pneumoniae, a Gram-positive pathogen that causes pneumonia, bacteremia, meningitis, and otitis media, contains 2236 predicted coding regions; of these, 1440 (64%) were assigned a biological role. Approximately 5% of the genome is composed of insertion sequences that may contribute to genome rearrangements through uptake of foreign DNA. Extracellular enzyme systems for the metabolism of polysaccharides and hexosamines provide a substantial source of carbon and nitrogen for S. pneumoniae and also damage host tissues and facilitate colonization. A motif identified within the signal peptide of proteins is potentially involved in targeting these proteins to the cell surface of low-guanine/cytosine (GC) Gram-positive species. Several surface-exposed proteins that may serve as potential vaccine candidates were identified. Comparative genome hybridization with DNA arrays revealed strain differences in S. pneumoniae that could contribute to differences in virulence and antigenicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tettelin, H -- Nelson, K E -- Paulsen, I T -- Eisen, J A -- Read, T D -- Peterson, S -- Heidelberg, J -- DeBoy, R T -- Haft, D H -- Dodson, R J -- Durkin, A S -- Gwinn, M -- Kolonay, J F -- Nelson, W C -- Peterson, J D -- Umayam, L A -- White, O -- Salzberg, S L -- Lewis, M R -- Radune, D -- Holtzapple, E -- Khouri, H -- Wolf, A M -- Utterback, T R -- Hansen, C L -- McDonald, L A -- Feldblyum, T V -- Angiuoli, S -- Dickinson, T -- Hickey, E K -- Holt, I E -- Loftus, B J -- Yang, F -- Smith, H O -- Venter, J C -- Dougherty, B A -- Morrison, D A -- Hollingshead, S K -- Fraser, C M -- R01 AI40645-01A1/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2001 Jul 20;293(5529):498-506.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉The Institute for Genomic Research (TIGR), 9712 Medical Center Drive, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11463916" target="_blank"〉PubMed〈/a〉
    Keywords: Antigens, Bacterial ; Bacterial Proteins/chemistry/genetics/immunology/metabolism ; Bacterial Vaccines ; Base Composition ; Carbohydrate Metabolism ; Carrier Proteins/genetics/metabolism ; Chromosomes, Bacterial/genetics ; Computational Biology ; DNA Transposable Elements ; DNA, Bacterial/chemistry/genetics ; Gene Duplication ; Genes, Bacterial ; *Genome, Bacterial ; Hexosamines/metabolism ; Oligonucleotide Array Sequence Analysis ; Recombination, Genetic ; Repetitive Sequences, Nucleic Acid ; *Sequence Analysis, DNA ; Species Specificity ; Streptococcus pneumoniae/*genetics/immunology/metabolism/*pathogenicity ; Virulence ; rRNA Operon
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Genome sequence of the PCE-dechlorinating bacterium Dehalococcoides ethenogenes (2005)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2005-01-08
    Description: Dehalococcoides ethenogenes is the only bacterium known to reductively dechlorinate the groundwater pollutants, tetrachloroethene (PCE) and trichloroethene, to ethene. Its 1,469,720-base pair chromosome contains large dynamic duplicated regions and integrated elements. Genes encoding 17 putative reductive dehalogenases, nearly all of which were adjacent to genes for transcription regulators, and five hydrogenase complexes were identified. These findings, plus a limited repertoire of other metabolic modes, indicate that D. ethenogenes is highly evolved to utilize halogenated organic compounds and H2. Diversification of reductive dehalogenase functions appears to have been mediated by recent genetic exchange and amplification. Genome analysis provides insights into the organism's complex nutrient requirements and suggests that an ancestor was a nitrogen-fixing autotroph.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Seshadri, Rekha -- Adrian, Lorenz -- Fouts, Derrick E -- Eisen, Jonathan A -- Phillippy, Adam M -- Methe, Barbara A -- Ward, Naomi L -- Nelson, William C -- Deboy, Robert T -- Khouri, Hoda M -- Kolonay, James F -- Dodson, Robert J -- Daugherty, Sean C -- Brinkac, Lauren M -- Sullivan, Steven A -- Madupu, Ramana -- Nelson, Karen E -- Kang, Katherine H -- Impraim, Marjorie -- Tran, Kevin -- Robinson, Jeffrey M -- Forberger, Heather A -- Fraser, Claire M -- Zinder, Stephen H -- Heidelberg, John F -- New York, N.Y. -- Science. 2005 Jan 7;307(5706):105-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. rekha@tigr.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15637277" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acids/biosynthesis ; Biodegradation, Environmental ; Chloroflexi/*genetics/*metabolism ; Gene Duplication ; Genes, Bacterial ; *Genome, Bacterial ; Hydrogen/metabolism ; Molecular Sequence Data ; Nitrogenase/genetics/metabolism ; Operon ; Oxidation-Reduction ; Oxidoreductases/genetics/metabolism ; Quinones/metabolism ; Sequence Analysis, DNA ; Tetrachloroethylene/*metabolism ; Transcription Factors/genetics/metabolism ; Water Pollutants, Chemical/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...