Publikationsdatum:
2012-11-20
Beschreibung:
Computational and learning theory models propose that behavioral control reflects value that is both cached (computed and stored during previous experience) and inferred (estimated on the fly on the basis of knowledge of the causal structure of the environment). The latter is thought to depend on the orbitofrontal cortex. Yet some accounts propose that the orbitofrontal cortex contributes to behavior by signaling "economic" value, regardless of the associative basis of the information. We found that the orbitofrontal cortex is critical for both value-based behavior and learning when value must be inferred but not when a cached value is sufficient. The orbitofrontal cortex is thus fundamental for accessing model-based representations of the environment to compute value rather than for signaling value per se.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592380/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592380/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Joshua L -- Esber, Guillem R -- McDannald, Michael A -- Gruber, Aaron J -- Hernandez, Alex -- Mirenzi, Aaron -- Schoenbaum, Geoffrey -- F32 DA031517/DA/NIDA NIH HHS/ -- F32-031517/PHS HHS/ -- R01 DA015718/DA/NIDA NIH HHS/ -- R01-DA015718/DA/NIDA NIH HHS/ -- ZIA DA000587-01/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2012 Nov 16;338(6109):953-6. doi: 10.1126/science.1227489.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy and Neurobiology, University of Maryland School of Medicine, 20 Penn Street, Baltimore, MD 21201, USA. josh.jones@nih.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23162000" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Animals
;
*Behavior, Animal
;
Conditioning (Psychology)
;
Cues
;
Frontal Lobe/*physiology
;
*Learning
;
Male
;
Rats
;
Rats, Inbred LEC
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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