ISSN:
1432-0983
Keywords:
Yeast
;
Mitochondrial
;
Frameshift-Suppression
;
15S rRNA
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The first case of a +1 “extrageneic” frameshift suppressor (MF1), mapping in the yeast mitochondrial 15S rRNA gene is reported. The suppressor was identified by genetic analyses in a leaky mitochondrial oxi1 frameshift mutant and the respective wild-type strain 777-3A of the yeast S. cerevisiae. This is in accordance with the finding that all mitochondrial frameshift mutants isolated from this strain tend to be leaky to a variable degree. MF1 does not suppress known nonsense mutations created by a direct basepair exchange in strain 777-3A. These mutants exhibit a non-leaky phenotype (Weiss-Brummer et al. 1984).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00355403
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