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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 3 (1971), S. 247-251 
    ISSN: 1432-1041
    Keywords: Flavonoids ; blood flow ; venous distensibility ; capillary filtration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We studied the effect of 0-(β-hydroxyethyl)-rutosides (HR), (Venoruton®, Zyma) upon resting blood flow, venous distensibility and capillary filtration coefficient in the calf in 5 women with idiopathic oedema. — During 60 min of i.v. infusion of 1000 mg HR, the value of the capillary filtration coefficient which is the measure of the size of the capillary filtration area decreased. — After 30 days peroral treatment with 3 × 300 mg HR per day the initial values of the capillary filtration coefficient were proved to have decreased. — After 30 days of oral treatment, the HR infusion was of equal effect upon decrease of the capillary filtration coefficient as in the first infusion before treatment. — No effect of the drug upon values of resting blood flow and venous distensibility was observed. — We believe HR to diminish the capillary area by causing constriction of the precapillary sphincters.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1041
    Keywords: Flavonoids ; blood flow ; capillary filtration ; venous distensibility ; capillary permeability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects have been investigated of a single intravenous dose of 1000 mg 0-(β-hydroxyethyl)-rutosides (HR), (Venoruton® Zyma) on the blood flow (BF), venous distensibility (VD), capillary filtration coefficient (CFC) and capillary diffusion capacity (CDC) in 27 patients with chronic venous insufficiency, and 9 subjects without cardiovascular disease, using venous occlusion plethysmography and isotope clearance techniques. During HR administration there was a significant fall in CFC whilst the other parameters were unchanged. It is considered that this is due to the mechanism of action of HR which reduces the size of the capillary bed by an effect on the precapillary sphincters.
    Type of Medium: Electronic Resource
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