ISSN:
0749-1581
Keywords:
1H NMR
;
13C NMR
;
Pseudolaric acid B
;
Diterpene
;
Conformation
;
Fertility regulation
;
Cytotoxicity
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The proton and carbon spectra for the fertility-regulating agent, pseudolaric acid B (1), have been assigned using a combination of one- and two-dimensional NMR spectroscopic techniques. NOE difference measurements revealed an unexpected conformation of the molecule, which could only be explained by a strained conformation of the six-membered lactone ring. Molecular forcefield calculations confirmed the presence of a low-energy conformer having the lactone ring in a half-planar conformation. The solution conformation is closely related to the solid-state conformation. Evaluation in a broad range of human cell lines established that 1 is a general cytotoxic agent.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260271104
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