Publication Date:
2008-10-31
Description:
It has long been known that the 5' to 3' polarity of DNA synthesis results in both a leading and lagging strand at all replication forks. Until now, however, there has been no evidence that leading or lagging strands are spatially organized in any way within a cell. Here we show that chromosome segregation in Escherichia coli is not random but is driven in a manner that results in the leading and lagging strands being addressed to particular cellular destinations. These destinations are consistent with the known patterns of chromosome segregation. Our work demonstrates a new level of organization relating to the replication and segregation of the E. coli chromosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉White, Martin A -- Eykelenboom, John K -- Lopez-Vernaza, Manuel A -- Wilson, Emily -- Leach, David R F -- G0401313/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- England -- Nature. 2008 Oct 30;455(7217):1248-50. doi: 10.1038/nature07282.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Cell Biology, School of Biological Sciences, University of Edinburgh, King's Buildings, Edinburgh EH9 3JR, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18972020" target="_blank"〉PubMed〈/a〉
Keywords:
Cephalexin/pharmacology
;
*Chromosome Segregation
;
Chromosomes, Bacterial/*genetics/*metabolism
;
DNA Replication
;
DNA, Bacterial/biosynthesis/genetics
;
Deoxyribonucleases/metabolism
;
Enzyme Induction/drug effects
;
Escherichia coli/*cytology/enzymology/*genetics
;
Escherichia coli Proteins/metabolism
;
Exonucleases/metabolism
;
Models, Biological
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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