ISSN:
0021-8383
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Microbial Reduction of 2,2-Disubstituted Cyclopentan-1,3-diones. Synthesis of Chiral Cyclopentane Derivatives Useful as Intermediates for 8-Methyl ProstaglandinsThe microbial reduction of the 2,2-disubstituted cyclopentan-1,3-diones 3a—c giving rise to the chiral compounds 2, 4b and 4c is described.The incubation products can be used as intermediates for 8-methyl prostaglandins.The structures of the fermentatively formed compounds, including their chirality and optical purity have been established by comparison with authentic specimen (cp. 2) or by chemical and spectroscopic methods (cp. 4b, 4c) respectively.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/prac.19813230505
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