Publication Date:
1981-10-09
Description:
Ethanol induces hemorrhagic gastric erosions and causes a dose-dependent decrease in the concentration of nonprotein sulfhydryl compounds in rat gastric mucosa. Sulfhydryl-containing drugs protect rats from ethanol-induced gastric erosions, whereas sulfhydryl blocking agents counteract the mucosal cytoprotective effect of prostaglandin F2 beta. These observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfhydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Szabo, S -- Trier, J S -- Frankel, P W -- AM05993/AM/NIADDK NIH HHS/ -- AM17537/AM/NIADDK NIH HHS/ -- AM25229/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Oct 9;214(4517):200-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7280691" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Ethanol/antagonists & inhibitors
;
Gastric Mucosa/*drug effects
;
Prostaglandins/physiology
;
Prostaglandins F/pharmacology
;
Rats
;
Sulfhydryl Compounds/*physiology
;
Sulfhydryl Reagents/*pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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